STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
barASensor-regulator; Activates OmpR by phophorylation; Code: T; COG: COG0642. (918 aa)    
Predicted Functional Partners:
uvrY
Putative 2-component transcriptional regulator; Code: TK; COG: COG2197.
 
 0.999
arcB
Aerobic respiration sensor-response protein; Histidine protein kinase/phosphatase, sensor for arcA; Code: T; COG: COG0642.
 
 
0.996
evgS
Putative sensor for regulator EvgA; Code: ET; COG: COG0834.
 
 
0.995
SDY_4127
Putative histidine kinase; Code: T; COG: COG0642.
 
 
0.987
yojN
Putative 2-component sensor protein; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsD is a phosphotransfer intermediate between the sensor kinase RcsC and the response regulator RcsB. It acquires a phosphoryl group from RcsC and transfers it to RcsB.
 
 
 0.983
rcsC
Sensor for ctr capsule biosynthesis; Component of the Rcs signaling system, which controls transcription of numerous genes. RcsC functions as a membrane- associated protein kinase that phosphorylates RcsD in response to environmental signals. The phosphoryl group is then transferred to the response regulator RcsB.
 
 
0.980
uhpA
Response regulator, positive activator of uhpT transcription; Sensor, uhpB; Code: TK; COG: COG2197.
 
 
 0.969
evgA
Putative positive transcription regulator; Sensor EvgS; Code: TK; COG: COG2197.
  
 
 0.965
narL
NarL; Pleiotrophic regulation of anaerobic respiration: response regulator for nar, frd, dms and tor genes; Code: TK; COG: COG2197.
 
 
 0.963
aer
Aerotaxis sensor receptor, flavoprotein; Code: NT; COG: COG0840.
  
 
 0.963
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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