STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tolCOuter membrane channel; Specific tolerance to colicin E1; segregation of daughter chromosomes; Code: MU; COG: COG1538. (495 aa)    
Predicted Functional Partners:
acrA
Acridine efflux pump; Code: M; COG: COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.997
acrB
Acridine efflux pump; Code: V; COG: COG0841.
 
 0.981
SDY_2383
Putative membrane protein; Code: M; COG: COG0845; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.978
SDY_1372
Putative multidrug-efflux transport protein; Code: V; COG: COG0841.
 
 0.943
SDY_1374
Putative outer membrane channel protein; Code: MU; COG: COG1538.
     
 0.908
emrA
Multidrug resistance secretion protein; Code: V; COG: COG1566.
  
 
 0.897
ompF
Outer membrane protein 1a (Ia;b;F); Code: M; COG: COG3203; Belongs to the Gram-negative porin family.
  
  
 0.893
yaeT
Conserved hypothetical protein; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery.
 
   
 0.891
ompC
Outer membrane protein 1b; Ib;c; Code: M; COG: COG3203; Belongs to the Gram-negative porin family.
  
  
 0.890
ybjZ
Putative ATP-binding component of a transport system; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.887
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
Server load: medium (42%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.