STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iccRegulator of lacZ; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)    
Predicted Functional Partners:
cyaA
Adenylate cyclase; Code: F; COG: COG3072; Belongs to the adenylyl cyclase class-1 family.
  
  
 0.962
yqiA
Conserved hypothetical protein; Code: R; COG: COG3150; orf.
 
  
 0.956
yqiB
Putative enzyme; Code: S; COG: COG3151.
 
  
 0.928
yqiE
Conserved hypothetical protein; Code: LR; COG: COG0494; orf.
   
 0.927
mazG
Conserved hypothetical protein; Code: R; COG: COG1694; orf.
  
  
  0.914
ushA
UDP-sugar hydrolase; 5'-nucleotidase; Code: F; COG: COG0737; Belongs to the 5'-nucleotidase family.
   
 
 0.912
adk
Adk; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.905
ygdH
Conserved hypothetical protein; Code: R; COG: COG1611; orf.
    
  0.902
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
  
 
  0.901
purB
Adenylosuccinate lyase; Code: F; COG: COG0015; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
     
  0.900
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.