STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hdeAConserved hypothetical protein; Required for optimal acid stress protection. Exhibits a chaperone-like activity only at low pH by suppressing non-specifically the aggregation of denaturated periplasmic proteins. Belongs to the HdeA family. (110 aa)    
Predicted Functional Partners:
hdeB
Conserved hypothetical protein; Required for optimal acid stress protection, which is important for survival of enteric bacteria in the acidic environment of the host stomach. Exhibits a chaperone-like activity at acidic pH by preventing the aggregation of many different periplasmic proteins. Belongs to the HdeB family.
  
  
 0.984
hdeD
Conserved hypothetical protein; Code: S; COG: COG3247; orf.
  
  
 0.948
xasA
Acid sensitivity protein, putative transporter; Code: E; COG: COG0531.
   
  
 0.870
yhiE
Conserved hypothetical protein; Code: K; COG: COG2771; orf.
   
  
 0.863
gadB
Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.
   
  
 0.681
gadA
Glutamate decarboxylase isozyme; Code: E; COG: COG0076; Belongs to the group II decarboxylase family.
   
  
 0.577
slp
Outer membrane protein induced after carbon starvation; Code: M; COG: COG3065.
   
  
 0.483
glnE
Adenylylating enzyme for glutamine synthetase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal trans [...]
      
 0.448
rpoS
RNA polymerase, sigma S factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the master transcriptional regulator of the stationary phase and the general stress response.
      
 0.417
yneH
Putative glutaminase; Code: E; COG: COG2066; Belongs to the glutaminase family.
   
  
 0.413
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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