STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
yifDATranscription regulator; Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon. (279 aa)    
Predicted Functional Partners:
seqA
Negative modulator of initiation of replication; Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated.
      
 0.783
yeiE
Putative transcriptional regulator LYSR-type; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.767
yfiE
Putative transcriptional regulator LYSR-type; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.762
nac
Nitrogen assimilation control protein; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.756
qseA
Similar to quorum sensing Escherichia coli regulator A; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.742
lysR
Positive regulator for lys; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.708
yhjC
Putative transcriptional regulator LYSR-type; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.670
cbl
Accessory regulatory circuit affecting cysM; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
    0.656
yeaT
Putative transcriptional regulator LYSR-type; Code: K; COG: COG0583; Belongs to the LysR transcriptional regulatory family.
  
     0.622
yifE
Conserved hypothetical protein; Code: S; COG: COG3085; orf.
 
   
 0.607
Your Current Organism:
Shigella dysenteriae
NCBI taxonomy Id: 300267
Other names: S. dysenteriae Sd197, Shigella dysenteriae Sd197, Shigella dysenteriae str. Sd197, Shigella dysenteriae strain Sd197
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