STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MetHMethionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. (1236 aa)    
Predicted Functional Partners:
metF
5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.998
metZ
O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide.
 
 
 0.989
metE
Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 
 0.986
CysJ
Sulfite reductase (NADPH) flavoprotein alpha-component.
  
 0.965
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
  
 
 0.961
metK
Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 
 0.960
SEJ46645.1
Homoserine dehydrogenase.
  
 
 0.953
gcvT
Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine.
  
 
 0.948
gcvT-2
Aminomethyltransferase.
  
 
 0.948
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
     
 0.939
Your Current Organism:
Pseudomonas oleovorans
NCBI taxonomy Id: 301
Other names: ATCC 17440 [[Pseudomonas pseudoalcaligenes]], ATCC 8062, CCUG 2087, CCUG 51525 [[Pseudomonas pseudoalcaligenes]], CFBP 2435 [[Pseudomonas pseudoalcaligenes]], CFBP 5589, CIP 59.11, CIP 66.14 [[Pseudomonas pseudoalcaligenes]], DSM 50188 [[Pseudomonas pseudoalcaligenes]], IFO 13583, IFO 14167 [[Pseudomonas pseudoalcaligenes]], JCM 11598, JCM 5968 [[Pseudomonas pseudoalcaligenes]], LMG 2229, LMG:2229, NBRC 13583, NBRC 14167 [[Pseudomonas pseudoalcaligenes]], NCCB 76045 [[Pseudomonas pseudoalcaligenes]], NCIB 6576, NCIMB 6576, NCTC 10692, NCTC 10860 [[Pseudomonas pseudoalcaligenes]], NRRL B-778, P. oleovorans, Pseudomonas pseudoalcaligenes, Pseudomonas pseudoalcaligenes subsp. pseudoalcaligenes, Pseudomonas sp. MGY01
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