rpmE protein (Caldibacillus debilis) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

rpmE

Hypothetical protein; Binds the 23S rRNA. (68 aa)

Predicted Functional Partners:

rplS

0.992

rpsP

0.992

rpsO

0.991

rpsT

0.990

rplU

0.990

rplM

0.988

rpmA

0.988

rpmB

0.987

rpmF

0.986

B4135_0388

0.985

Your Current Organism:

Caldibacillus debilis

NCBI taxonomy Id: 301148
Other names: C. debilis, Caldibacillus debilis (Banat et al. 2004) Coorevits et al. 2012, DSM 16016, Geobacillus debilis, Geobacillus debilis Banat et al. 2004, LMG 23386, LMG:23386, NCIMB 13995, strain R-35653, strain Tf

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B4135_0388	rplM	B4135_0388	B4135_0071	LSU ribosomal protein L20p.	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.997
B4135_0388	rplS	B4135_0388	B4135_3773	LSU ribosomal protein L20p.	Hypothetical protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.993
B4135_0388	rplU	B4135_0388	B4135_3351	LSU ribosomal protein L20p.	Hypothetical protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.994
B4135_0388	rpmA	B4135_0388	B4135_3349	LSU ribosomal protein L20p.	LSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family.	0.993
B4135_0388	rpmB	B4135_0388	B4135_3810	LSU ribosomal protein L20p.	LSU ribosomal protein L28p; Belongs to the bacterial ribosomal protein bL28 family.	0.980
B4135_0388	rpmE	B4135_0388	B4135_0785	LSU ribosomal protein L20p.	Hypothetical protein; Binds the 23S rRNA.	0.985
B4135_0388	rpmF	B4135_0388	B4135_2754	LSU ribosomal protein L20p.	LSU ribosomal protein L32p; Belongs to the bacterial ribosomal protein bL32 family.	0.992
B4135_0388	rpsO	B4135_0388	B4135_3698	LSU ribosomal protein L20p.	Hypothetical protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.	0.994
B4135_0388	rpsP	B4135_0388	B4135_3779	LSU ribosomal protein L20p.	SSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family.	0.991
B4135_0388	rpsT	B4135_0388	B4135_3241	LSU ribosomal protein L20p.	Hypothetical protein; Binds directly to 16S ribosomal RNA.	0.975
rplM	B4135_0388	B4135_0071	B4135_0388	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	LSU ribosomal protein L20p.	0.997
rplM	rplS	B4135_0071	B4135_3773	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	Hypothetical protein; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.992
rplM	rplU	B4135_0071	B4135_3351	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	Hypothetical protein; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.992
rplM	rpmA	B4135_0071	B4135_3349	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	LSU ribosomal protein L27p; Belongs to the bacterial ribosomal protein bL27 family.	0.994
rplM	rpmB	B4135_0071	B4135_3810	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	LSU ribosomal protein L28p; Belongs to the bacterial ribosomal protein bL28 family.	0.991
rplM	rpmE	B4135_0071	B4135_0785	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	Hypothetical protein; Binds the 23S rRNA.	0.988
rplM	rpmF	B4135_0071	B4135_2754	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	LSU ribosomal protein L32p; Belongs to the bacterial ribosomal protein bL32 family.	0.991
rplM	rpsO	B4135_0071	B4135_3698	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	Hypothetical protein; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.	0.994
rplM	rpsP	B4135_0071	B4135_3779	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	SSU ribosomal protein S16p; Belongs to the bacterial ribosomal protein bS16 family.	0.993
rplM	rpsT	B4135_0071	B4135_3241	Hypothetical protein; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	Hypothetical protein; Binds directly to 16S ribosomal RNA.	0.991

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Network Stats

number of nodes:

3

number of edges:

3

average node degree:

2

avg. local clustering coefficient:

1

expected number of edges:

2

PPI enrichment p-value:

0.211

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004691

cAMP-dependent protein kinase activity

2 of 4

2.77

0.9

0.0236

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:18772

Mixed, incl. Synaptotagmin-like mitochondrial-lipid-binding domain, and tRNA-dihydrouridine synthase, conserved site

3 of 7

2.71

2.1

0.00014

CL:2622

CREB1 phosphorylation through the activation of Adenylate Cyclase, and Urea transport

2 of 10

2.38

0.78

0.0383

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04140

Autophagy - animal

3 of 141

1.4

0.67

0.0390

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-442720

CREB1 phosphorylation through the activation of Adenylate Cyclase

3 of 7

2.71

2.21

8.53e-05

MAP-438064

Post NMDA receptor activation events

3 of 19

2.27

1.76

0.00047

MAP-111931

PKA-mediated phosphorylation of CREB

3 of 18

2.3

1.76

0.00047

MAP-1489509

DAG and IP3 signaling

3 of 26

2.14

1.66

0.00064

MAP-111997

CaM pathway

3 of 26

2.14

1.66

0.00064

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0446

Lipid-binding

3 of 8

2.65

2.52

2.11e-05

KW-0445

Lipid transport

3 of 15

2.38

2.26

5.20e-05

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR031468

Synaptotagmin-like mitochondrial-lipid-binding domain

3 of 4

2.95

2.26

7.73e-05

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