STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NCSTNNicastrin. (717 aa)    
Predicted Functional Partners:
psenen
Presenilin enhancer, gamma-secretase subunit.
    
 0.999
aph1a
APH1B gamma secretase subunit.
   
 0.996
LOC102207316
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.991
psen2
Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family.
   
 0.991
LOC102204142
Notch receptor 1a.
    
 0.974
notch1
Notch receptor 1b.
    
 0.974
APP
Amyloid beta precursor protein.
    
 0.926
LOC102215690
Amyloid beta (A4) precursor protein b.
    
 0.926
LOC102201575
Notch receptor 3.
    
 0.902
LOC102204172
Notch receptor 2.
    
 0.902
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.