STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENSPNYP00000009154SH2 domain-containing protein. (373 aa)    
Predicted Functional Partners:
pdgfrb
Platelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells.
    
 0.955
LOC102214691
Insulin receptor substrate 2a.
    
 0.941
LOC102197083
Insulin receptor substrate 4a.
    
 0.941
LOC102195437
Insulin receptor substrate 2b.
    
 0.941
LOC102197086
Si:ch73-335l21.1.
    
 0.941
LOC102199942
Si:ch211-284e13.4.
    
 0.940
LOC102203517
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.938
pik3cd
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit.
    
 0.938
pik3cb
Phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta; Belongs to the PI3/PI4-kinase family.
    
 0.938
LOC102198584
PH domain-containing protein.
    
 0.926
Your Current Organism:
Pundamilia nyererei
NCBI taxonomy Id: 303518
Other names: Haplochromis nyererei, P. nyererei
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.