JF72_12730 protein (Lactobacillus apis) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

JF72_12730

Na+-H+ antiporter. (607 aa)

Predicted Functional Partners:

JF72_11680

0.797

JF72_07840

0.753

JF72_03360

0.704

pacL1

0.704

JF72_12010

0.704

dnaJ

0.688

JF72_02820

0.668

ppnK

0.646

nadD

0.640

JF72_04130

0.630

Your Current Organism:

Lactobacillus apis

NCBI taxonomy Id: 303541
Other names: CCM 8403, L. apis, LMG 26964, LMG:26964, Lactobacillus apis Killer et al. 2014, Lactobacillus sp. ESL0185, Lactobacillus sp. R4B, Lactobacillus sp. R4C, strain R4B

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
JF72_02820	JF72_12730	JF72_02820	JF72_12730	Small-conductance mechanosensitive channel.	Na+-H+ antiporter.	0.668
JF72_03360	JF72_12730	JF72_03360	JF72_12730	Cation-transporting P-type ATPase.	Na+-H+ antiporter.	0.704
JF72_04130	JF72_12730	JF72_04130	JF72_12730	Phosphocarrier protein HPr.	Na+-H+ antiporter.	0.630
JF72_07840	JF72_12730	JF72_07840	JF72_12730	Cation-transporting ATPase.	Na+-H+ antiporter.	0.753
JF72_11680	JF72_12730	JF72_11680	JF72_12730	Uncharacterized protein.	Na+-H+ antiporter.	0.797
JF72_12010	JF72_12730	JF72_12010	JF72_12730	Magnesium-importing ATPase.	Na+-H+ antiporter.	0.704
JF72_12730	JF72_02820	JF72_12730	JF72_02820	Na+-H+ antiporter.	Small-conductance mechanosensitive channel.	0.668
JF72_12730	JF72_03360	JF72_12730	JF72_03360	Na+-H+ antiporter.	Cation-transporting P-type ATPase.	0.704
JF72_12730	JF72_04130	JF72_12730	JF72_04130	Na+-H+ antiporter.	Phosphocarrier protein HPr.	0.630
JF72_12730	JF72_07840	JF72_12730	JF72_07840	Na+-H+ antiporter.	Cation-transporting ATPase.	0.753
JF72_12730	JF72_11680	JF72_12730	JF72_11680	Na+-H+ antiporter.	Uncharacterized protein.	0.797
JF72_12730	JF72_12010	JF72_12730	JF72_12010	Na+-H+ antiporter.	Magnesium-importing ATPase.	0.704
JF72_12730	dnaJ	JF72_12730	JF72_07890	Na+-H+ antiporter.	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	0.688
JF72_12730	nadD	JF72_12730	JF72_09160	Na+-H+ antiporter.	Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	0.640
JF72_12730	pacL1	JF72_12730	JF72_04240	Na+-H+ antiporter.	H+-K+-exchanging ATPase.	0.704
JF72_12730	ppnK	JF72_12730	JF72_04210	Na+-H+ antiporter.	Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.646
dnaJ	JF72_12730	JF72_07890	JF72_12730	Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]	Na+-H+ antiporter.	0.688
nadD	JF72_12730	JF72_09160	JF72_12730	Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Na+-H+ antiporter.	0.640
nadD	ppnK	JF72_09160	JF72_04210	Putative nicotinate-nucleotide adenylyltransferase; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).	Putative inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.954
pacL1	JF72_12730	JF72_04240	JF72_12730	H+-K+-exchanging ATPase.	Na+-H+ antiporter.	0.704

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Network Stats

number of nodes:

9

number of edges:

19

average node degree:

4.22

avg. local clustering coefficient:

0.858

expected number of edges:

9

PPI enrichment p-value:

0.00314

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006914

Autophagy

5 of 90

1.7

1.88

8.13e-05

GO:0061709

Reticulophagy

2 of 4

2.66

1.02

0.0187

GO:0016236

Macroautophagy

3 of 46

1.77

0.93

0.0187

GO:0000422

Autophagy of mitochondrion

2 of 8

2.35

0.89

0.0289

GO:0034727

Piecemeal microautophagy of the nucleus

2 of 14

2.11

0.75

0.0495

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000407

Phagophore assembly site

4 of 25

2.16

2.64

1.04e-05

GO:0034045

Phagophore assembly site membrane

3 of 13

2.32

2.15

0.00014

GO:0005773

Vacuole

6 of 186

1.46

1.83

1.04e-05

GO:0005776

Autophagosome

2 of 2

2.96

1.7

0.0013

GO:0005774

Vacuolar membrane

4 of 133

1.43

1.22

0.0015

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:11059

Mixed, incl. Autophagy - other, and Organic cation transport

6 of 37

2.17

4.3

1.61e-09

CL:11064

Autophagy - other, and Lipase (class 3)

4 of 23

2.2

2.87

3.83e-06

CL:11096

Atg1/ULK1 kinase complex, and Phagophore assembly site

3 of 7

2.59

2.64

2.39e-05

CL:11119

Mixed, incl. Peptidase M18, and Lysosomal oligosaccharide catabolism

2 of 7

2.41

1.24

0.0071

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04136

Autophagy - other

4 of 23

2.2

3.03

1.72e-06

map04138

Autophagy - yeast

4 of 98

1.57

1.61

0.00020

map04139

Mitophagy - yeast

3 of 48

1.75

1.51

0.00091

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-9612973

Autophagy

5 of 60

1.88

2.59

3.13e-06

MAP-1632852

Macroautophagy

5 of 60

1.88

2.59

3.13e-06

MAP-9663891

Selective autophagy

3 of 30

1.96

1.51

0.0015

MAP-8934903

Receptor Mediated Mitophagy

2 of 9

2.3

1.07

0.0137

MAP-5205647

Mitophagy

2 of 19

1.98

0.78

0.0415

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0034045

Phagophore assembly site membrane

3 of 15

2.26

1.76

0.00073

GOCC:0005776

Autophagosome

2 of 2

2.96

1.58

0.0021

GOCC:0034270

Cvt complex

2 of 3

2.78

1.52

0.0026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0072

Autophagy

2 of 9

2.3

1.08

0.0132

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