node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
C662_04905 | C662_06699 | C662_04905 | C662_06699 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.629 |
C662_04905 | dnaJ | C662_04905 | C662_01040 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.629 |
C662_04905 | grpE | C662_04905 | C662_01050 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.655 |
C662_04905 | hslU | C662_04905 | C662_04885 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.658 |
C662_04905 | hslV | C662_04905 | C662_04880 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.763 |
C662_04905 | htpG | C662_04905 | C662_13521 | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.559 |
C662_06699 | C662_04905 | C662_06699 | C662_04905 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | RNA-binding S4 domain-containing protein; COG1188 Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit (S4 paralog). | 0.629 |
C662_06699 | C662_09633 | C662_06699 | C662_09633 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | 0.751 |
C662_06699 | groEL | C662_06699 | C662_07343 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.905 |
C662_06699 | groS | C662_06699 | C662_07348 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.755 |
C662_06699 | grpE | C662_06699 | C662_01050 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.973 |
C662_06699 | hslU | C662_06699 | C662_04885 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATP-dependent protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis. | 0.861 |
C662_06699 | hslV | C662_06699 | C662_04880 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATP-dependent protease subunit HslV; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. | 0.802 |
C662_06699 | htpG | C662_06699 | C662_13521 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | Heat shock protein 90; Molecular chaperone. Has ATPase activity. | 0.993 |
C662_06699 | lon | C662_06699 | C662_08035 | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.713 |
C662_09633 | C662_06699 | C662_09633 | C662_06699 | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | Heat shock protein DnaJ; COG0484 DnaJ-class molecular chaperone with C-terminal Zn finger domain. | 0.751 |
C662_09633 | dnaJ | C662_09633 | C662_01040 | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...] | 0.713 |
C662_09633 | groEL | C662_09633 | C662_07343 | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.769 |
C662_09633 | groS | C662_09633 | C662_07348 | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | Chaperonin Cpn10; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.497 |
C662_09633 | grpE | C662_09633 | C662_01050 | ATPase AAA; COG0466 ATP-dependent Lon protease, bacterial type. | Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...] | 0.784 |