STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
actPAcetate permease; COG4147 Predicted symporter; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (558 aa)    
Predicted Functional Partners:
C662_17148
COG3162 Predicted membrane protein.
 
  
 0.992
C662_08340
Signal transduction protein; COG0517 FOG: CBS domain.
 
  
 0.706
C662_08155
Putative nucleotidyltransferase; COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains.
 
  
 0.676
C662_08160
COG0847 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases.
  
    0.548
C662_05712
Hypothetical protein; COG2905 Predicted signal-transduction protein containing cAMP-binding and CBS domains.
  
  
 0.537
C662_17143
COG1024 Enoyl-CoA hydratase/carnithine racemase.
  
    0.534
acsA
acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family.
 
  
 0.473
prpE
COG0365 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases.
 
  
 0.461
Your Current Organism:
Thauera sp. 28
NCBI taxonomy Id: 303682
Server load: low (32%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.