node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A1V6SSN0 | A0A1V6T1U8 | A0A1V6SSN0 | A0A1V6T1U8 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 0.978 |
A0A1V6SSN0 | A0A1V6T5Q7 | A0A1V6SSN0 | A0A1V6T5Q7 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | AAA domain-containing protein. | 0.863 |
A0A1V6SSN0 | A0A1V6T6Z5 | A0A1V6SSN0 | A0A1V6T6Z5 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Checkpoint protein; Belongs to the HUS1 family. | 0.924 |
A0A1V6SSN0 | A0A1V6TD22 | A0A1V6SSN0 | A0A1V6TD22 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | AAA domain-containing protein. | 0.863 |
A0A1V6SSN0 | A0A1V6TEC2 | A0A1V6SSN0 | A0A1V6TEC2 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Uncharacterized protein. | 0.915 |
A0A1V6SSN0 | A0A1V6TM72 | A0A1V6SSN0 | A0A1V6TM72 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.997 |
A0A1V6SSN0 | A0A1V6TVE6 | A0A1V6SSN0 | A0A1V6TVE6 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | AAA domain-containing protein. | 0.871 |
A0A1V6SSN0 | A0A1V6TY66 | A0A1V6SSN0 | A0A1V6TY66 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 3'-5' exonuclease domain-containing protein. | 0.999 |
A0A1V6SSN0 | A0A1V6U192 | A0A1V6SSN0 | A0A1V6U192 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. | 0.906 |
A0A1V6SSN0 | FEN1 | A0A1V6SSN0 | A0A1V6TVQ6 | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.823 |
A0A1V6T1U8 | A0A1V6SSN0 | A0A1V6T1U8 | A0A1V6SSN0 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein; Belongs to the PI3/PI4-kinase family. | 0.978 |
A0A1V6T1U8 | A0A1V6T5Q7 | A0A1V6T1U8 | A0A1V6T5Q7 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | AAA domain-containing protein. | 0.884 |
A0A1V6T1U8 | A0A1V6T6Z5 | A0A1V6T1U8 | A0A1V6T6Z5 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Checkpoint protein; Belongs to the HUS1 family. | 0.907 |
A0A1V6T1U8 | A0A1V6TD22 | A0A1V6T1U8 | A0A1V6TD22 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | AAA domain-containing protein. | 0.870 |
A0A1V6T1U8 | A0A1V6TEC2 | A0A1V6T1U8 | A0A1V6TEC2 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Uncharacterized protein. | 0.900 |
A0A1V6T1U8 | A0A1V6TM72 | A0A1V6T1U8 | A0A1V6TM72 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. | 0.901 |
A0A1V6T1U8 | A0A1V6TVE6 | A0A1V6T1U8 | A0A1V6TVE6 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | AAA domain-containing protein. | 0.902 |
A0A1V6T1U8 | A0A1V6TY66 | A0A1V6T1U8 | A0A1V6TY66 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | 3'-5' exonuclease domain-containing protein. | 0.999 |
A0A1V6T1U8 | A0A1V6U192 | A0A1V6T1U8 | A0A1V6U192 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | DNA repair protein rad9; Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation. | 0.959 |
A0A1V6T1U8 | FEN1 | A0A1V6T1U8 | A0A1V6TVQ6 | Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] | 0.861 |