N306_03922 protein (Opisthocomus hoazin) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

N306_03922

Osteopetrosis-associated transmembrane protein 1. (199 aa)

Predicted Functional Partners:

N306_05481

0.991

N306_05320

0.893

N306_00837

0.893

N306_01103

0.794

N306_11475

0.760

N306_06715

0.760

N306_06714

0.760

N306_03923

0.720

N306_06954

0.529

N306_09911

0.515

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N306_00837	N306_03922	A0A091W4Q2	A0A091V9B2	Chloride channel protein D.	Osteopetrosis-associated transmembrane protein 1.	0.893
N306_01103	N306_03922	A0A091WI55	A0A091V9B2	Chloride channel protein.	Osteopetrosis-associated transmembrane protein 1.	0.794
N306_03922	N306_00837	A0A091V9B2	A0A091W4Q2	Osteopetrosis-associated transmembrane protein 1.	Chloride channel protein D.	0.893
N306_03922	N306_01103	A0A091V9B2	A0A091WI55	Osteopetrosis-associated transmembrane protein 1.	Chloride channel protein.	0.794
N306_03922	N306_03923	A0A091V9B2	A0A091VAB2	Osteopetrosis-associated transmembrane protein 1.	Translocation protein SEC63.	0.720
N306_03922	N306_05320	A0A091V9B2	A0A091V9X5	Osteopetrosis-associated transmembrane protein 1.	Chloride transport protein 6; Belongs to the chloride channel (TC 2.A.49) family.	0.893
N306_03922	N306_05481	A0A091V9B2	A0A091XFI0	Osteopetrosis-associated transmembrane protein 1.	Chloride channel protein.	0.991
N306_03922	N306_06714	A0A091V9B2	A0A091WS13	Osteopetrosis-associated transmembrane protein 1.	Protein WWC3.	0.760
N306_03922	N306_06715	A0A091V9B2	A0A091WQ00	Osteopetrosis-associated transmembrane protein 1.	Chloride channel protein.	0.760
N306_03922	N306_06954	A0A091V9B2	A0A091W8I5	Osteopetrosis-associated transmembrane protein 1.	TraB domain-containing protein.	0.529
N306_03922	N306_09911	A0A091V9B2	A0A091WIC4	Osteopetrosis-associated transmembrane protein 1.	Queuine tRNA-ribosyltransferase subunit QTRTD1.	0.515
N306_03922	N306_11475	A0A091V9B2	A0A091WGH5	Osteopetrosis-associated transmembrane protein 1.	Protein WWC2.	0.760
N306_03923	N306_03922	A0A091VAB2	A0A091V9B2	Translocation protein SEC63.	Osteopetrosis-associated transmembrane protein 1.	0.720
N306_05320	N306_03922	A0A091V9X5	A0A091V9B2	Chloride transport protein 6; Belongs to the chloride channel (TC 2.A.49) family.	Osteopetrosis-associated transmembrane protein 1.	0.893
N306_05481	N306_03922	A0A091XFI0	A0A091V9B2	Chloride channel protein.	Osteopetrosis-associated transmembrane protein 1.	0.991
N306_06714	N306_03922	A0A091WS13	A0A091V9B2	Protein WWC3.	Osteopetrosis-associated transmembrane protein 1.	0.760
N306_06715	N306_03922	A0A091WQ00	A0A091V9B2	Chloride channel protein.	Osteopetrosis-associated transmembrane protein 1.	0.760
N306_06954	N306_03922	A0A091W8I5	A0A091V9B2	TraB domain-containing protein.	Osteopetrosis-associated transmembrane protein 1.	0.529
N306_06954	N306_09911	A0A091W8I5	A0A091WIC4	TraB domain-containing protein.	Queuine tRNA-ribosyltransferase subunit QTRTD1.	0.508
N306_09911	N306_03922	A0A091WIC4	A0A091V9B2	Queuine tRNA-ribosyltransferase subunit QTRTD1.	Osteopetrosis-associated transmembrane protein 1.	0.515

page 1 of 2

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.869

expected number of edges:

13

PPI enrichment p-value:

1.41e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006506

GPI anchor biosynthetic process

4 of 30

2.59

3.1

1.48e-06

GO:0009398

FMN biosynthetic process

2 of 2

3.47

2.13

0.00015

GO:0090407

Organophosphate biosynthetic process

6 of 572

1.49

1.83

8.75e-06

GO:1901137

Carbohydrate derivative biosynthetic process

6 of 638

1.44

1.74

1.06e-05

GO:0019637

Organophosphate metabolic process

7 of 939

1.34

1.61

7.64e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008531

Riboflavin kinase activity

2 of 2

3.47

1.59

0.0014

GO:0003919

FMN adenylyltransferase activity

2 of 5

3.07

1.45

0.0024

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030176

Integral component of endoplasmic reticulum membrane

2 of 70

1.92

0.72

0.0441

GO:0005789

Endoplasmic reticulum membrane

4 of 653

1.25

0.61

0.0419

GO:0031984

Organelle subcompartment

5 of 1567

0.97

0.52

0.0419

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:12625

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 15

2.89

3.7

1.51e-07

CL:12628

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

3 of 10

2.94

2.71

1.12e-05

CL:9572

Purine nucleotide salvage, and Adenylate kinase activity

3 of 31

2.45

1.99

0.00019

CL:9944

Mixed, incl. Calcineurin-like phosphoesterase, and Nicotinamide nucleotide metabolic process

3 of 46

2.28

1.84

0.00032

CL:9958

Riboflavin kinase domain superfamily, and Nudix N-terminal

2 of 5

3.07

1.67

0.00098

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00563

Glycosylphosphatidylinositol (GPI)-anchor biosynthesis

4 of 29

2.6

3.87

4.55e-08

map00740

Riboflavin metabolism

3 of 79

2.04

1.86

0.00020

map01100

Metabolic pathways

9 of 6166

0.63

0.51

0.00067

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163125

Post-translational modification: synthesis of GPI-anchored proteins

4 of 30

2.59

3.46

2.92e-07

MAP-196843

Vitamin B2 (riboflavin) metabolism

2 of 6

2.99

1.6

0.0013

MAP-162710

Synthesis of glycosylphosphatidylinositol (GPI)

2 of 19

2.49

1.2

0.0063

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0042765

GPI-anchor transamidase complex

2 of 6

2.99

1.33

0.0040

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR023198

Phosphoglycolate phosphatase-like, domain 2

4 of 13

2.95

3.79

1.10e-07

IPR023465

Riboflavin kinase domain superfamily

3 of 3

3.47

3.34

9.32e-07

IPR015865

Riboflavin kinase domain, bacterial/eukaryotic

3 of 3

3.47

3.34

9.32e-07

IPR006439

HAD hydrolase, subfamily IA

4 of 26

2.65

3.31

6.34e-07

IPR041492

Haloacid dehalogenase-like hydrolase

4 of 28

2.62

3.3

6.34e-07

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00904

Riboflavin kinase

2 of 2

3.47

1.94

0.00033

Enrichment display settings

Enrichment analysis is still ongoing, please wait ...

Server load: low (12%) [HD]

Permalink

Credits

Access

Info

About

STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.

Network

Fusion

Experiments

Cooccurrence

Databases

Neighborhood

Textmining

Coexpression

© STRING Consortium 2024

Credits

Access

Info

About