N306_05539 protein (Opisthocomus hoazin) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

N306_05539

Eukaryotic peptide chain release factor GTP-binding subunit ERF3A. (506 aa)

Predicted Functional Partners:

N306_11859

0.953

N306_12315

0.940

N306_02817

0.901

N306_01098

0.898

N306_10160

0.897

N306_01997

0.897

N306_12529

0.888

N306_03873

0.881

N306_02954

0.879

N306_07043

0.878

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N306_01098	N306_01997	A0A091WLZ7	A0A091W6A9	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	0.878
N306_01098	N306_02817	A0A091WLZ7	A0A091XHE6	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	40S ribosomal protein S3a.	0.999
N306_01098	N306_02954	A0A091WLZ7	A0A091WPR4	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	40S ribosomal protein S6.	0.999
N306_01098	N306_03873	A0A091WLZ7	A0A091VPQ1	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	60S ribosomal protein L4.	0.999
N306_01098	N306_05539	A0A091WLZ7	A0A091WBA1	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A.	0.898
N306_01098	N306_07043	A0A091WLZ7	A0A091WK23	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	60S ribosomal protein L5.	0.999
N306_01098	N306_10160	A0A091WLZ7	A0A091VST4	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family.	0.970
N306_01098	N306_11859	A0A091WLZ7	A0A091WLQ6	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	Eukaryotic peptide chain release factor subunit 1.	0.875
N306_01098	N306_12529	A0A091WLZ7	A0A091WCF3	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	60S acidic ribosomal protein P0.	0.999
N306_01997	N306_01098	A0A091W6A9	A0A091WLZ7	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.878
N306_01997	N306_02817	A0A091W6A9	A0A091XHE6	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	40S ribosomal protein S3a.	0.885
N306_01997	N306_02954	A0A091W6A9	A0A091WPR4	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	40S ribosomal protein S6.	0.810
N306_01997	N306_03873	A0A091W6A9	A0A091VPQ1	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	60S ribosomal protein L4.	0.839
N306_01997	N306_05539	A0A091W6A9	A0A091WBA1	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	Eukaryotic peptide chain release factor GTP-binding subunit ERF3A.	0.897
N306_01997	N306_07043	A0A091W6A9	A0A091WK23	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	60S ribosomal protein L5.	0.833
N306_01997	N306_10160	A0A091W6A9	A0A091VST4	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	Elongation factor 1-beta; Belongs to the EF-1-beta/EF-1-delta family.	0.985
N306_01997	N306_12529	A0A091W6A9	A0A091WCF3	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	60S acidic ribosomal protein P0.	0.889
N306_02817	N306_01098	A0A091XHE6	A0A091WLZ7	40S ribosomal protein S3a.	40S ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family.	0.999
N306_02817	N306_01997	A0A091XHE6	A0A091W6A9	40S ribosomal protein S3a.	Elongation factor 1-delta; Belongs to the EF-1-beta/EF-1-delta family.	0.885
N306_02817	N306_02954	A0A091XHE6	A0A091WPR4	40S ribosomal protein S3a.	40S ribosomal protein S6.	0.999

page 1 of 5

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.9

expected number of edges:

5

PPI enrichment p-value:

0.0777

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006635

Fatty acid beta-oxidation

3 of 10

2.17

1.46

0.0017

GO:0006631

Fatty acid metabolic process

4 of 42

1.68

1.3

0.0017

GO:0006629

Lipid metabolic process

5 of 172

1.16

0.94

0.0018

GO:0006412

Translation

4 of 105

1.28

0.92

0.0048

GO:0044238

Primary metabolic process

10 of 1831

0.43

0.33

0.0097

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

4 of 55

1.56

1.17

0.0026

GO:0070403

NAD+ binding

2 of 3

2.52

1.14

0.0084

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

4 of 61

1.51

1.34

0.00069

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3915

Lipid oxidation, and 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

4 of 13

2.19

2.34

2.54e-05

CL:2855

Ribosome

4 of 33

1.78

0.00014

CL:4722

Oxidoreductase FAD-binding domain, and Response to nitrosative stress

2 of 6

2.22

1.15

0.0070

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

rsi00360

Phenylalanine metabolism

5 of 15

2.22

3.73

1.96e-08

rsi00650

Butanoate metabolism

3 of 20

1.87

1.7

0.00030

rsi00362

Benzoate degradation

3 of 22

1.83

1.67

0.00031

rsi03010

Ribosome

4 of 54

1.57

1.61

0.00013

rsi00903

Limonene and pinene degradation

2 of 4

2.4

1.61

0.0010

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0036125

Fatty acid beta-oxidation multienzyme complex

3 of 6

2.4

2.02

0.00016

GOCC:0005840

Ribosome

4 of 37

1.73

1.72

0.00016

GOCC:0062077

phenylacetyl-CoA 1,2-epoxidase complex

2 of 3

2.52

1.34

0.0034

GOCC:0022627

Cytosolic small ribosomal subunit

2 of 7

2.15

1.11

0.0082

GOCC:0032991

Protein-containing complex

7 of 574

0.78

0.59

0.0034

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

4 of 64

1.49

1.22

0.0014

KW-0001

2Fe-2S

2 of 8

2.1

1.04

0.0111

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF16113

Enoyl-CoA hydratase/isomerase

3 of 8

2.27

1.67

0.00069

PF02737

3-hydroxyacyl-CoA dehydrogenase, NAD binding domain

2 of 3

2.52

1.04

0.0129

PF00970

Oxidoreductase FAD-binding domain

2 of 3

2.52

1.04

0.0129

PF00725

3-hydroxyacyl-CoA dehydrogenase, C-terminal domain

2 of 3

2.52

1.04

0.0129

PF00175

Oxidoreductase NAD-binding domain

2 of 3

2.52

1.04

0.0129

(more ...)

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