N306_05549 protein (Opisthocomus hoazin) - STRING interaction network

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

N306_05549

Multidrug resistance-associated protein 1. (1509 aa)

Predicted Functional Partners:

KATNAL2

0.683

N306_11654

0.636

N306_04453

0.633

N306_11152

0.618

N306_00263

0.605

N306_01844

0.602

N306_08395

0.602

N306_09237

0.602

N306_00560

0.602

N306_09647

0.602

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KATNAL2	N306_04453	A0A091XSW2	A0A091WDE7	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Spermatogenesis-associated protein 5.	0.495
KATNAL2	N306_05549	A0A091XSW2	A0A091WBB2	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Multidrug resistance-associated protein 1.	0.683
KATNAL2	N306_11152	A0A091XSW2	A0A091WLF0	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	Hydroxysteroid dehydrogenase-like 2.	0.756
N306_00263	N306_05549	A0A091VMC1	A0A091WBB2	Golgi-associated PDZ and coiled-coil motif-containing protein.	Multidrug resistance-associated protein 1.	0.605
N306_00560	N306_01844	A0A091W7P7	A0A091VKC2	G protein-activated inward rectifier potassium channel 1.	G protein-activated inward rectifier potassium channel 4.	0.910
N306_00560	N306_05549	A0A091W7P7	A0A091WBB2	G protein-activated inward rectifier potassium channel 1.	Multidrug resistance-associated protein 1.	0.602
N306_00560	N306_09237	A0A091W7P7	A0A091W188	G protein-activated inward rectifier potassium channel 1.	G protein-activated inward rectifier potassium channel 2.	0.860
N306_01844	N306_00560	A0A091VKC2	A0A091W7P7	G protein-activated inward rectifier potassium channel 4.	G protein-activated inward rectifier potassium channel 1.	0.910
N306_01844	N306_05549	A0A091VKC2	A0A091WBB2	G protein-activated inward rectifier potassium channel 4.	Multidrug resistance-associated protein 1.	0.602
N306_01844	N306_08395	A0A091VKC2	A0A091VLG3	G protein-activated inward rectifier potassium channel 4.	G protein-activated inward rectifier potassium channel 1.	0.910
N306_01844	N306_09237	A0A091VKC2	A0A091W188	G protein-activated inward rectifier potassium channel 4.	G protein-activated inward rectifier potassium channel 2.	0.857
N306_04453	KATNAL2	A0A091WDE7	A0A091XSW2	Spermatogenesis-associated protein 5.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.495
N306_04453	N306_05549	A0A091WDE7	A0A091WBB2	Spermatogenesis-associated protein 5.	Multidrug resistance-associated protein 1.	0.633
N306_05549	KATNAL2	A0A091WBB2	A0A091XSW2	Multidrug resistance-associated protein 1.	Katanin p60 ATPase-containing subunit A-like 2; Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.	0.683
N306_05549	N306_00263	A0A091WBB2	A0A091VMC1	Multidrug resistance-associated protein 1.	Golgi-associated PDZ and coiled-coil motif-containing protein.	0.605
N306_05549	N306_00560	A0A091WBB2	A0A091W7P7	Multidrug resistance-associated protein 1.	G protein-activated inward rectifier potassium channel 1.	0.602
N306_05549	N306_01844	A0A091WBB2	A0A091VKC2	Multidrug resistance-associated protein 1.	G protein-activated inward rectifier potassium channel 4.	0.602
N306_05549	N306_04453	A0A091WBB2	A0A091WDE7	Multidrug resistance-associated protein 1.	Spermatogenesis-associated protein 5.	0.633
N306_05549	N306_08395	A0A091WBB2	A0A091VLG3	Multidrug resistance-associated protein 1.	G protein-activated inward rectifier potassium channel 1.	0.602
N306_05549	N306_09237	A0A091WBB2	A0A091W188	Multidrug resistance-associated protein 1.	G protein-activated inward rectifier potassium channel 2.	0.602

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

13

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006357

Regulation of transcription by RNA polymerase II

8 of 408

1.35

1.97

5.32e-08

GO:0006355

Regulation of transcription, DNA-templated

10 of 600

1.28

1.93

2.60e-09

GO:0050794

Regulation of cellular process

11 of 1543

0.91

1.04

3.23e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003712

Transcription coregulator activity

7 of 67

2.08

4.38

9.55e-11

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016592

Mediator complex

8 of 18

2.71

8.48

1.42e-17

GO:0140513

Nuclear protein-containing complex

9 of 629

1.21

1.66

4.54e-08

GO:0005634

Nucleus

11 of 2417

0.72

0.68

3.91e-06

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:24339748

(2013) A downy mildew effector attenuates salicylic acid-triggered immunity in Arabidopsis by interacting with the host mediator complex.

2 of 2

3.06

1.92

0.00033

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1661

Activator

6 of 6

3.06

7.39

1.69e-14

CL:1618

RNA Polymerase II Promoter Escape, and Mediator complex

8 of 30

2.48

7.22

9.19e-16

CL:1605

DNA-directed RNA polymerase complex, and Mediator complex

10 of 140

1.91

5.23

9.19e-16

CL:1863

Mediator complex

2 of 7

2.51

1.3

0.0041

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-212436

Generic Transcription Pathway

10 of 308

1.57

3.25

9.49e-13

MAP-73857

RNA Polymerase II Transcription

10 of 454

1.4

2.49

2.15e-11

MAP-74160

Gene expression (Transcription)

10 of 631

1.26

1.94

3.68e-10

MAP-2173796

SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription

2 of 8

2.46

1.16

0.0074

MAP-2173793

Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer

2 of 13

2.24

1.01

0.0137

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990508

CKM complex

2 of 2

3.06

1.58

0.0014

GOCC:0005634

Nucleus

10 of 1424

0.9

0.94

3.64e-06

GOCC:0032991

Protein-containing complex

10 of 2455

0.67

0.56

0.00038

GOCC:0043229

Intracellular organelle

11 of 4296

0.47

0.37

0.0019

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0010

Activator

6 of 18

2.58

5.87

2.74e-12

KW-0805

Transcription regulation

6 of 133

1.71

2.72

8.78e-08

KW-0539

Nucleus

6 of 365

1.27

1.46

1.57e-05

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