N306_05756 protein (Opisthocomus hoazin) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

N306_05756

Lamin-B receptor. (614 aa)

Predicted Functional Partners:

N306_06597

0.986

N306_02761

0.942

N306_03206

0.926

N306_11250

0.917

N306_02470

0.917

N306_01435

0.913

N306_13863

0.913

N306_00192

0.911

N306_03601

0.879

N306_02908

0.851

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N306_00192	N306_01435	A0A091VDI6	A0A091WG19	Putative ergosterol biosynthetic protein 28.	3-keto-steroid reductase.	0.980
N306_00192	N306_02470	A0A091VDI6	A0A091X7X4	Putative ergosterol biosynthetic protein 28.	Delta(24)-sterol reductase.	0.508
N306_00192	N306_02761	A0A091VDI6	A0A091WAP8	Putative ergosterol biosynthetic protein 28.	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.867
N306_00192	N306_03206	A0A091VDI6	A0A091XE57	Putative ergosterol biosynthetic protein 28.	Squalene monooxygenase.	0.701
N306_00192	N306_03601	A0A091VDI6	A0A091WQ84	Putative ergosterol biosynthetic protein 28.	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.	0.867
N306_00192	N306_05756	A0A091VDI6	A0A091WDT5	Putative ergosterol biosynthetic protein 28.	Lamin-B receptor.	0.911
N306_00192	N306_06597	A0A091VDI6	A0A091WA76	Putative ergosterol biosynthetic protein 28.	Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family.	0.983
N306_00192	N306_11250	A0A091VDI6	A0A091WNB2	Putative ergosterol biosynthetic protein 28.	Sigma non-opioid intracellular receptor 1.	0.979
N306_00192	N306_13863	A0A091VDI6	A0A091XE18	Putative ergosterol biosynthetic protein 28.	Cholesterol 25-hydroxylase-like; Belongs to the sterol desaturase family.	0.867
N306_01435	N306_00192	A0A091WG19	A0A091VDI6	3-keto-steroid reductase.	Putative ergosterol biosynthetic protein 28.	0.980
N306_01435	N306_02470	A0A091WG19	A0A091X7X4	3-keto-steroid reductase.	Delta(24)-sterol reductase.	0.912
N306_01435	N306_02761	A0A091WG19	A0A091WAP8	3-keto-steroid reductase.	Methylsterol monooxygenase 1; Belongs to the sterol desaturase family.	0.975
N306_01435	N306_03206	A0A091WG19	A0A091XE57	3-keto-steroid reductase.	Squalene monooxygenase.	0.658
N306_01435	N306_03601	A0A091WG19	A0A091WQ84	3-keto-steroid reductase.	Fatty acid hydroxylase domain-containing protein 2; Belongs to the sterol desaturase family.	0.946
N306_01435	N306_05756	A0A091WG19	A0A091WDT5	3-keto-steroid reductase.	Lamin-B receptor.	0.913
N306_01435	N306_06597	A0A091WG19	A0A091WA76	3-keto-steroid reductase.	Lanosterol 14-alpha demethylase; Belongs to the cytochrome P450 family.	0.991
N306_01435	N306_11250	A0A091WG19	A0A091WNB2	3-keto-steroid reductase.	Sigma non-opioid intracellular receptor 1.	0.579
N306_01435	N306_13863	A0A091WG19	A0A091XE18	3-keto-steroid reductase.	Cholesterol 25-hydroxylase-like; Belongs to the sterol desaturase family.	0.962
N306_02470	N306_00192	A0A091X7X4	A0A091VDI6	Delta(24)-sterol reductase.	Putative ergosterol biosynthetic protein 28.	0.508
N306_02470	N306_01435	A0A091X7X4	A0A091WG19	Delta(24)-sterol reductase.	3-keto-steroid reductase.	0.912

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

22

average node degree:

4

avg. local clustering coefficient:

0.83

expected number of edges:

15

PPI enrichment p-value:

0.0417

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 114

1.55

3.35

2.24e-14

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

9 of 55

1.78

4.0

1.47e-12

GO:0019843

rRNA binding

7 of 42

1.78

3.3

2.02e-09

GO:0003723

RNA binding

8 of 121

1.38

2.08

2.56e-08

GO:0000049

tRNA binding

4 of 28

1.72

1.74

0.00013

GO:0003676

Nucleic acid binding

9 of 504

0.81

0.76

5.43e-05

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005840

Ribosome

9 of 63

1.72

3.82

8.73e-13

GO:0015935

Small ribosomal subunit

3 of 6

2.26

2.33

3.03e-05

GO:0005622

Intracellular anatomical structure

11 of 1355

0.47

0.41

0.00014

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:23342046

(2013) The genome sequences of Cellulomonas fimi and Cellvibrio gilvus reveal the cellulolytic strategies of two facultative anaerobes, transfer of Cellvibrio gilvus to the genus Cellulomonas, and proposal of Cellulomonas gilvus sp. nov.

3 of 32

1.53

0.95

0.0091

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:162

Ribosome

9 of 43

1.88

4.66

9.85e-14

CL:166

rRNA-binding

7 of 28

1.96

4.23

3.68e-11

CL:169

rRNA-binding

5 of 15

2.08

3.46

3.66e-08

CL:133

Translation, and Protein export

11 of 136

1.47

2.97

9.85e-14

CL:173

mRNA binding, and rRNA-binding

3 of 6

2.26

2.21

5.49e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

sde03010

Ribosome

9 of 53

1.79

4.26

1.58e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005840

Ribosome

7 of 52

1.69

2.92

9.28e-09

GOCC:0022626

Cytosolic ribosome

5 of 29

1.8

2.55

1.03e-06

GOCC:0044391

Ribosomal subunit

5 of 33

1.74

2.44

1.23e-06

GOCC:0022627

Cytosolic small ribosomal subunit

3 of 13

1.92

1.77

0.00024

GOCC:0043229

Intracellular organelle

9 of 280

1.07

1.29

3.19e-07

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

9 of 55

1.78

4.11

4.44e-13

KW-0699

rRNA-binding

7 of 39

1.82

3.57

3.82e-10

KW-0820

tRNA-binding

3 of 19

1.76

1.43

0.0010

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