N306_03360 protein (Opisthocomus hoazin) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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Databases

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[Homology]

Score

N306_03360

Uncharacterized protein. (440 aa)

Predicted Functional Partners:

N306_12368

0.989

N306_06773

0.931

N306_07023

0.930

N306_10886

0.920

N306_11462

0.915

N306_02753

0.914

N306_15628

0.882

N306_12026

0.872

N306_02968

0.842

N306_07100

0.821

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N306_02753	N306_03360	A0A091XH81	A0A091WJZ1	Uncharacterized protein.	Uncharacterized protein.	0.914
N306_02753	N306_11462	A0A091XH81	A0A091X917	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.927
N306_02968	N306_03360	A0A091WP42	A0A091WJZ1	Uncharacterized protein.	Uncharacterized protein.	0.842
N306_02968	N306_06773	A0A091WP42	A0A091WB39	Uncharacterized protein.	Cytochrome b.	0.948
N306_02968	N306_07100	A0A091WP42	A0A091VLH1	Uncharacterized protein.	Uncharacterized protein.	0.994
N306_02968	N306_10886	A0A091WP42	A0A091WLF3	Uncharacterized protein.	Uncharacterized protein.	0.999
N306_02968	N306_12026	A0A091WP42	A0A091WCT9	Uncharacterized protein.	Uncharacterized protein C1orf198.	0.999
N306_02968	N306_12368	A0A091WP42	A0A091WJC6	Uncharacterized protein.	Uncharacterized protein.	0.860
N306_02968	N306_15628	A0A091WP42	A0A091WDY0	Uncharacterized protein.	Uncharacterized protein.	0.999
N306_03360	N306_02753	A0A091WJZ1	A0A091XH81	Uncharacterized protein.	Uncharacterized protein.	0.914
N306_03360	N306_02968	A0A091WJZ1	A0A091WP42	Uncharacterized protein.	Uncharacterized protein.	0.842
N306_03360	N306_06773	A0A091WJZ1	A0A091WB39	Uncharacterized protein.	Cytochrome b.	0.931
N306_03360	N306_07023	A0A091WJZ1	A0A091XSG7	Uncharacterized protein.	Cytochrome c heme lyase; Links covalently the heme group to the apoprotein of cytochrome c.	0.930
N306_03360	N306_07100	A0A091WJZ1	A0A091VLH1	Uncharacterized protein.	Uncharacterized protein.	0.821
N306_03360	N306_10886	A0A091WJZ1	A0A091WLF3	Uncharacterized protein.	Uncharacterized protein.	0.920
N306_03360	N306_11462	A0A091WJZ1	A0A091X917	Uncharacterized protein.	Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX.	0.915
N306_03360	N306_12026	A0A091WJZ1	A0A091WCT9	Uncharacterized protein.	Uncharacterized protein C1orf198.	0.872
N306_03360	N306_12368	A0A091WJZ1	A0A091WJC6	Uncharacterized protein.	Uncharacterized protein.	0.989
N306_03360	N306_15628	A0A091WJZ1	A0A091WDY0	Uncharacterized protein.	Uncharacterized protein.	0.882
N306_06773	N306_02968	A0A091WB39	A0A091WP42	Cytochrome b.	Uncharacterized protein.	0.948

page 1 of 4

Network Stats

number of nodes:

7

number of edges:

21

average node degree:

6

avg. local clustering coefficient:

1

expected number of edges:

7

PPI enrichment p-value:

6.46e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016079

Synaptic vesicle exocytosis

3 of 14

2.89

2.81

3.61e-05

GO:0006887

Exocytosis

4 of 92

2.2

2.58

3.61e-05

GO:0048791

Calcium ion-regulated exocytosis of neurotransmitter

2 of 3

3.39

2.33

0.00024

GO:0016192

Vesicle-mediated transport

5 of 664

1.44

1.6

0.00011

GO:0140029

Exocytic process

2 of 30

2.39

1.33

0.0074

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019905

Syntaxin binding

3 of 37

2.47

2.2

0.00027

GO:0005484

SNAP receptor activity

2 of 40

2.26

0.88

0.0403

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098793

Presynapse

5 of 109

2.22

4.07

3.57e-08

GO:0008021

Synaptic vesicle

3 of 46

2.38

2.54

6.10e-05

GO:0070161

Anchoring junction

4 of 281

1.72

1.95

0.00011

GO:0030672

Synaptic vesicle membrane

2 of 21

2.54

1.71

0.0019

GO:0031201

SNARE complex

2 of 43

2.23

1.36

0.0061

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:26734

Norepinephrine Neurotransmitter Release Cycle, and Rim-like

3 of 10

3.04

3.08

1.42e-05

CL:26699

Mixed, incl. Organic anion transporters, and Regulated exocytosis

4 of 94

2.19

2.78

1.42e-05

CL:6761

SNARE complex disassembly, and Other interleukin signaling

2 of 6

3.08

2.15

0.00044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04130

SNARE interactions in vesicular transport

2 of 56

2.11

1.09

0.0167

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-449836

Other interleukin signaling

2 of 8

2.96

1.61

0.0031

MAP-181429

Serotonin Neurotransmitter Release Cycle

2 of 7

3.02

1.61

0.0031

MAP-212676

Dopamine Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-210500

Glutamate Neurotransmitter Release Cycle

2 of 11

2.82

1.6

0.0031

MAP-181430

Norepinephrine Neurotransmitter Release Cycle

2 of 9

2.91

1.6

0.0031

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0098793

Presynapse

5 of 68

2.43

4.8

4.28e-09

GOCC:0045202

Synapse

6 of 249

1.94

3.88

4.28e-09

GOCC:0030672

Synaptic vesicle membrane

3 of 19

2.76

3.26

5.98e-06

GOCC:0048788

Cytoskeleton of presynaptic active zone

2 of 5

3.16

2.42

0.00017

GOCC:0031410

Cytoplasmic vesicle

4 of 672

1.34

1.21

0.0012

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR039032

Rim-like

2 of 3

3.39

1.61

0.0032

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