N306_05999 protein (Opisthocomus hoazin) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

N306_05999

Protein CASC3. (480 aa)

Predicted Functional Partners:

N306_11572

0.998

N306_01038

0.987

N306_07525

0.984

N306_08201

0.981

N306_08203

0.981

N306_08202

0.981

N306_08195

0.909

N306_15099

0.909

N306_11547

0.867

N306_03484

0.850

Your Current Organism:

Opisthocomus hoazin

NCBI taxonomy Id: 30419
Other names: O. hoazin, Opisthocomus hoazin hoazin, hoatzin

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
N306_01038	N306_05999	A0A091X2M4	A0A091XIZ9	Regulator of nonsense transcripts 1.	Protein CASC3.	0.987
N306_01038	N306_07525	A0A091X2M4	A0A091WGX7	Regulator of nonsense transcripts 1.	Protein mago nashi 2.	0.810
N306_01038	N306_08195	A0A091X2M4	A0A091V606	Regulator of nonsense transcripts 1.	Regulator of nonsense transcripts 3A.	0.959
N306_01038	N306_11547	A0A091X2M4	A0A091WRW2	Regulator of nonsense transcripts 1.	Regulator of nonsense transcripts 2.	0.996
N306_01038	N306_11572	A0A091X2M4	A0A091W9W0	Regulator of nonsense transcripts 1.	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family.	0.889
N306_01038	N306_15099	A0A091X2M4	A0A091W587	Regulator of nonsense transcripts 1.	Regulator of nonsense transcripts 3B.	0.959
N306_03484	N306_05999	A0A091VKV0	A0A091XIZ9	Intron-binding protein aquarius.	Protein CASC3.	0.850
N306_03484	N306_07525	A0A091VKV0	A0A091WGX7	Intron-binding protein aquarius.	Protein mago nashi 2.	0.738
N306_03484	N306_08201	A0A091VKV0	A0A091V613	Intron-binding protein aquarius.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.702
N306_03484	N306_08202	A0A091VKV0	A0A091V8Q0	Intron-binding protein aquarius.	E3 SUMO-protein ligase RanBP2.	0.702
N306_03484	N306_08203	A0A091VKV0	A0A091V6Q7	Intron-binding protein aquarius.	E3 SUMO-protein ligase RanBP2.	0.702
N306_03484	N306_11572	A0A091VKV0	A0A091W9W0	Intron-binding protein aquarius.	Eukaryotic initiation factor 4A-III; Belongs to the DEAD box helicase family.	0.945
N306_05999	N306_01038	A0A091XIZ9	A0A091X2M4	Protein CASC3.	Regulator of nonsense transcripts 1.	0.987
N306_05999	N306_03484	A0A091XIZ9	A0A091VKV0	Protein CASC3.	Intron-binding protein aquarius.	0.850
N306_05999	N306_07525	A0A091XIZ9	A0A091WGX7	Protein CASC3.	Protein mago nashi 2.	0.984
N306_05999	N306_08195	A0A091XIZ9	A0A091V606	Protein CASC3.	Regulator of nonsense transcripts 3A.	0.909
N306_05999	N306_08201	A0A091XIZ9	A0A091V613	Protein CASC3.	Peptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family.	0.981
N306_05999	N306_08202	A0A091XIZ9	A0A091V8Q0	Protein CASC3.	E3 SUMO-protein ligase RanBP2.	0.981
N306_05999	N306_08203	A0A091XIZ9	A0A091V6Q7	Protein CASC3.	E3 SUMO-protein ligase RanBP2.	0.981
N306_05999	N306_11547	A0A091XIZ9	A0A091WRW2	Protein CASC3.	Regulator of nonsense transcripts 2.	0.867

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Network Stats

number of nodes:

11

number of edges:

34

average node degree:

6.18

avg. local clustering coefficient:

0.72

expected number of edges:

15

PPI enrichment p-value:

2.66e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006094

Gluconeogenesis

3 of 29

2.38

2.19

7.07e-05

GO:0044283

Small molecule biosynthetic process

8 of 672

1.44

2.18

5.43e-08

GO:1901607

Alpha-amino acid biosynthetic process

5 of 201

1.76

2.17

1.04e-05

GO:0006096

Glycolytic process

4 of 108

1.94

2.03

6.07e-05

GO:0019284

L-methionine salvage from S-adenosylmethionine

2 of 3

3.19

2.02

0.00023

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016860

Intramolecular oxidoreductase activity

5 of 69

2.23

3.34

1.72e-07

GO:0004347

glucose-6-phosphate isomerase activity

3 of 3

3.37

3.26

1.28e-06

GO:0046570

Methylthioribulose 1-phosphate dehydratase activity

2 of 2

3.37

1.86

0.00044

GO:0043874

Acireductone synthase activity

2 of 2

3.37

1.86

0.00044

GO:0043716

2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate phosphatase activity

2 of 2

3.37

1.86

0.00044

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:13634

L-serine biosynthetic process

3 of 11

2.8

2.33

5.40e-05

CL:13538

Mixed, incl. One carbon pool by folate, and De novo IMP biosynthetic process

4 of 59

2.2

2.19

5.40e-05

CL:14077

L-methionine salvage from S-adenosylmethionine, and S-methyl-5-thioribose kinase activity

2 of 5

2.97

1.3

0.0044

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pda00030

Pentose phosphate pathway

2 of 70

1.82

0.76

0.0346

pda01200

Carbon metabolism

3 of 304

1.36

0.67

0.0346

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-70171

Glycolysis

4 of 86

2.04

2.17

3.83e-05

MAP-70326

Glucose metabolism

4 of 132

1.85

1.88

0.00010

MAP-70263

Gluconeogenesis

3 of 93

1.88

1.32

0.0023

MAP-977347

Serine biosynthesis

2 of 16

2.46

1.29

0.0043

MAP-5628897

TP53 Regulates Metabolic Genes

3 of 144

1.69

1.14

0.0043

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0312

Gluconeogenesis

2 of 2

3.37

1.94

0.00032

KW-0324

Glycolysis

2 of 47

2.0

0.8

0.0309

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00342

Phosphoglucose isomerase

2 of 2

3.37

1.48

0.0022

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