STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCP_0020Conserved hypothetical protein; Belongs to the Protein of unknown function DUF1119, archaea family (IPR010545). (282 aa)    
Predicted Functional Partners:
topA-2
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
 
     0.707
MCP_0048
Conserved hypothetical protein.
  
     0.695
MCP_2297
Conserved hypothetical protein; Belongs to the Protein of unknown function DUF1621 family (IPR012426).
  
     0.695
MCP_0003
Conserved hypothetical protein.
  
     0.693
MCP_0292
Conserved hypothetical protein.
  
     0.686
MCP_2246
Conserved hypothetical protein; Belongs to the Protein of unknown function DUF106, transmembrane family (IPR002809).
  
     0.685
MCP_2999
Putative signal sequence peptidase.
  
     0.681
MCP_2850
Conserved hypothetical protein.
  
     0.680
MCP_2705
Putative oligosaccharyl transferase.
  
     0.674
MCP_1018
Conserved hypothetical protein.
  
     0.670
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.