Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCP_0154Putative phosphoesterase; Contains one TrkA-N domain (IPR003148). (473 aa)    
Predicted Functional Partners:
dacZ
Conserved hypothetical protein; Diadenylate cyclase that catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP is a second messenger for intracellular signal transduction involved in the control of important regulatory processes such as osmoregulation.
   
 0.658
MCP_2845
Conserved hypothetical protein; Belongs to the Protein of unknown function UPF0153 family (IPR005358).
 
    0.593
MCP_2513
Aspartate kinase; Belongs to the aspartokinase family.
       0.582
mptE
Conserved hypothetical protein; Catalyzes the transfer of diphosphate from ATP to 6- hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl- 7,8-dihydropterin diphosphate (6-HMDP); Belongs to the archaeal 6-HMPDK family.
       0.536
MCP_2839
Conserved hypothetical protein; Contains one Elongator protein 3/MiaB/NifBdomain (IPR006638); Contains one Radical SAM domain (IPR007197).
       0.536
MCP_0627
Putative chromosome segregation and condensation protein ScpA.
 
    0.519
MCP_1328
Putative bacterial type II secretion system protein.
  
     0.507
MCP_0371
Putative TatD deoxyribonuclease.
  
     0.490
cofC
Conserved hypothetical protein; Guanylyltransferase that catalyzes the activation of phosphoenolpyruvate (PEP) as enolpyruvoyl-2-diphospho-5'-guanosine, via the condensation of PEP with GTP. It is involved in the biosynthesis of coenzyme F420, a hydride carrier cofactor; Belongs to the CofC family.
 
     0.484
MCP_1981
Conserved hypothetical protein; Contains at least one Cystathionine-beta-synthasedomain (IPR000644); Contains one ParB-like nuclease domain (IPR003115).
 
    0.473
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.