Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
echAEch hydrogenase subunit A. (633 aa)    
Predicted Functional Partners:
echF
Ech hydrogenase subunit F.
 
 
 0.995
MCP_2639
Putative hydrogenase membrane component.
 
 
 0.993
echB
Ech hydrogenase subunit B.
   
 0.990
MCP_2640
Putative [NiFe]-hydrogenase large subunit.
 
 
 0.990
echD
Ech hydrogenase subunit D.
  
 
 0.981
echC
Ech hydrogenase subunit C.
 
  
 0.952
echE
Ech hydrogenase subunit E.
 
  
 0.933
MCP_2638
4Fe-4S ferredoxin, iron-sulfur binding protein.
  
 
 0.933
MCP_0523
[NiFe]-hydrogenase large subunit; Similar to Ech hydrogenase, subunit EchE in Methanosarcina barkeri (O59656).
 
  
 0.714
pcm
protein-L-isoaspartate O-methyltransferase; Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.
  
   0.640
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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