Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MCP_0574Conserved hypothetical protein; Contains one PilT protein, N-terminal domain (IPR002716); Contains one Nucleotide binding protein, PINc domain (IPR006596).; Contains one Bacterial type II secretion system protein E domain (IPR001482).; Contains one KH, type 1 domain (IPR004088). (610 aa)    
Predicted Functional Partners:
hisI
phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.
       0.841
MCP_1254
Putative A24 family peptidase.
     
 0.619
MCP_1467
Belongs to the Conserved hypothetical protein 61 family (IPR004425).
  
   
 0.612
MCP_2661
Archaeal histone.
 
     0.586
hisS
histidyl-tRNA synthetase; Belongs to the class-II aminoacyl-tRNA synthetase family.
 
     0.584
MCP_2438
Asparagine synthase.
       0.582
alaS
alanyl-tRNA synthetase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.
 
     0.565
rps8e
30S ribosomal protein S8e.
  
     0.545
MCP_1835
Conserved hypothetical protein; Belongs to the Band 7 protein family (IPR001107); Belongs to the Stomatin family (IPR001972).
      
 0.538
tfe
Transcription initiation factor E; Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation comple [...]
  
     0.537
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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