STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pan-2Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] (412 aa)    
Predicted Functional Partners:
psmA
Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
 0.969
psmB
Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.
  
 0.958
rpl40e
50S ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
   
 0.947
MCP_0188
Conserved hypothetical protein.
  
 0.943
MCP_1751
Conserved hypothetical protein; Similar to JAMM-like protein in Archaeoglobus fulgidus (O28085, AF_2198).
  
 0.943
pan-1
Proteasome-activating nucleotidase; Belongs to the AAA ATPase family.
  
  
 
0.903
MCP_2698
Protein kinase; Contains at least one Tetratricopeptide region domain (IPR013026); Contains at least three Tetratricopeptide TPR_1 repeats (IPR001440).; Contains at least five Tetratricopeptide TPR_2repeats (IPR013105).
  
 0.858
MCP_0330
Putative S1 family peptidase.
  
 0.834
MCP_0995
Putative S1 family peptidase.
  
 0.834
MCP_1660
Putative S1 family peptidase.
  
 0.834
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.