Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
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[Homology]
Score
MCP_1150Glyoxalase family protein. (133 aa)    
Predicted Functional Partners:
MCP_1151
Putative phosphohydrolase.
 
  
 0.683
echF
Ech hydrogenase subunit F.
  
  
 0.641
MCP_2638
4Fe-4S ferredoxin, iron-sulfur binding protein.
  
  
 0.641
pycA
Putative pyruvate carboxylase subunit A.
  
    0.617
MCP_0234
Phosphopantetheinyl transferase.
  
 
 0.580
MCP_1667
Conserved hypothetical protein.
 
   
 0.460
MCP_1152
Conserved hypothetical protein.
  
    0.442
MCP_0635
Putative isochorismatase hydrolase.
 
  
 0.420
MCP_0826
Conserved hypothetical protein.
  
     0.415
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
  
 0.404
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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