STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ahcYAdenosylhomocysteinase; Catalyzes the hydrolysis of S-inosyl-L-homocysteine (SIH) to L-homocysteine (Hcy) and inosine. Likely functions in a S-adenosyl-L- methionine (SAM) recycling pathway from S-adenosyl-L-homocysteine (SAH) produced from SAM-dependent methylation reactions. Can also catalyze the reverse reaction in vitro, i.e. the synthesis of SIH from Hcy and inosine; Belongs to the adenosylhomocysteinase family. (418 aa)    
Predicted Functional Partners:
metE
Putative methylcobalamin:homocysteine methyltransferase.
  
 
 0.981
MCP_0132
Conserved hypothetical protein; Contains one CBS domain (IPR000644); Contains one Protein of unknown function DUF39 domain (IPR002708).
     
  0.900
MCP_0133
Putative ferredoxin.
     
  0.900
metK
S-adenosylmethionine synthetase.
  
 
 0.855
MCP_1345
Putative carbohydrate kinase.
  
 
 0.841
cysC
Putative adenylyl-sulfate kinase.
     
 0.841
MCP_1713
Homoserine dehydrogenase.
  
 
 0.835
thrB
Homoserine kinase; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
    
  0.802
MCP_1346
Conserved hypothetical protein.
       0.776
fbp/suhB
Putative inositol-1-monophosphatase/fructose-1, 6-bisphosphatase; Similar to Extragenic suppressor in Pyrococcus furiosus (Q8TZH9); Similar to Inositol-1-monophosphatase in Methanococcus jannaschii (Q57573).; bifunctional protein.
     
 0.774
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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