Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pdhCPyruvate dehydrogenase E2 component. (405 aa)    
Predicted Functional Partners:
pdhA
Pyruvate dehydrogenase E1 component alpha subunit.
 
 0.999
pdhB
Pyruvate dehydrogenase E1 component beta subunit.
 0.999
pdhD
Putative pyruvate dehydrogenase E3 component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 0.999
MCP_0970
Putative FAD-dependent pyridine nucleotide-disulphide oxidoreductase; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.
 0.996
lipA
Probable lipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.
 
 
 0.982
pycA
Putative pyruvate carboxylase subunit A.
  
 
 0.949
MCP_2748
acyl-CoA C-acyltransferases.
  
 
 0.943
prs-1
Ribose-phosphate pyrophosphokinase; Belongs to the ribose-phosphate pyrophosphokinase family.
  
 0.939
prs-2
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P).
  
 0.939
MCP_1721
Putative biotin/lipoate A/B protein ligase.
 
 0.930
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.