node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCP_0713 | ppnK | MCP_0713 | MCP_1736 | Conserved hypothetical protein; Contains one RNA-binding S4 domain (IPR002942); Contains one Methyltransferase type 12 domain (IPR013217). | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.683 |
MCP_0713 | srp54 | MCP_0713 | MCP_2655 | Conserved hypothetical protein; Contains one RNA-binding S4 domain (IPR002942); Contains one Methyltransferase type 12 domain (IPR013217). | Signal recognition 54 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.467 |
MCP_1737 | ppnK | MCP_1737 | MCP_1736 | Conserved hypothetical protein. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.551 |
MCP_2311 | nadE-1 | MCP_2311 | MCP_0270 | Nicotinamide-nucleotide adenylyltransferase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.940 |
MCP_2311 | nadE-2 | MCP_2311 | MCP_0445 | Nicotinamide-nucleotide adenylyltransferase. | NH(3)-dependent NAD(+) synthetase. | 0.930 |
MCP_2311 | ppnK | MCP_2311 | MCP_1736 | Nicotinamide-nucleotide adenylyltransferase. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.926 |
MCP_2698 | ppnK | MCP_2698 | MCP_1736 | Protein kinase; Contains at least one Tetratricopeptide region domain (IPR013026); Contains at least three Tetratricopeptide TPR_1 repeats (IPR001440).; Contains at least five Tetratricopeptide TPR_2repeats (IPR013105). | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.623 |
MCP_2698 | srp54 | MCP_2698 | MCP_2655 | Protein kinase; Contains at least one Tetratricopeptide region domain (IPR013026); Contains at least three Tetratricopeptide TPR_1 repeats (IPR001440).; Contains at least five Tetratricopeptide TPR_2repeats (IPR013105). | Signal recognition 54 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.408 |
fbp/suhB | ppnK | MCP_1348 | MCP_1736 | Putative inositol-1-monophosphatase/fructose-1, 6-bisphosphatase; Similar to Extragenic suppressor in Pyrococcus furiosus (Q8TZH9); Similar to Inositol-1-monophosphatase in Methanococcus jannaschii (Q57573).; bifunctional protein. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.814 |
glyA | pdhD | MCP_0294 | MCP_1720 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Putative pyruvate dehydrogenase E3 component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | 0.936 |
glyA | ppnK | MCP_0294 | MCP_1736 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.577 |
glyA | srp54 | MCP_0294 | MCP_2655 | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Signal recognition 54 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY. Belongs to the GTP-binding SRP family. SRP54 subfamily. | 0.557 |
nadE-1 | MCP_2311 | MCP_0270 | MCP_2311 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Nicotinamide-nucleotide adenylyltransferase. | 0.940 |
nadE-1 | nadE-2 | MCP_0270 | MCP_0445 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | NH(3)-dependent NAD(+) synthetase. | 0.913 |
nadE-1 | ppnK | MCP_0270 | MCP_1736 | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.939 |
nadE-2 | MCP_2311 | MCP_0445 | MCP_2311 | NH(3)-dependent NAD(+) synthetase. | Nicotinamide-nucleotide adenylyltransferase. | 0.930 |
nadE-2 | nadE-1 | MCP_0445 | MCP_0270 | NH(3)-dependent NAD(+) synthetase. | NH(3)-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source. | 0.913 |
nadE-2 | ppnK | MCP_0445 | MCP_1736 | NH(3)-dependent NAD(+) synthetase. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.941 |
pdhD | glyA | MCP_1720 | MCP_0294 | Putative pyruvate dehydrogenase E3 component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. Also exhibits THF-independent aldolase activity toward beta- hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.936 |
pdhD | ppnK | MCP_1720 | MCP_1736 | Putative pyruvate dehydrogenase E3 component; Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. | Probable inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. | 0.928 |