Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
MCP_1925Conserved hypothetical protein; Contains one Radical SAM domain (IPR007197); Contains one Protein of unknown function DUF512 domain (IPR007549). (432 aa)    
Predicted Functional Partners:
mcrA
Methyl-coenzyme M reductase alpha subunit; Component of the methyl-coenzyme M reductase (MCR) I that catalyzes the reductive cleavage of methyl-coenzyme M (CoM-S-CH3 or 2- (methylthio)ethanesulfonate) using coenzyme B (CoB or 7- mercaptoheptanoylthreonine phosphate) as reductant which results in the production of methane and the mixed heterodisulfide of CoB and CoM (CoM-S-S-CoB). This is the final step in methanogenesis.
   
 
 0.936
mcrB
Methyl-coenzyme M reductase beta subunit.
       0.529
MCP_1005
Putative adenylate kinase; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Belongs to the adenylate kinase family. AK6 subfamily.
       0.529
MCP_1926
Hypothetical protein.
       0.500
mcrC
Methyl-coenzyme M reductase operon protein C.
       0.462
MCP_0554
Conserved hypothetical protein; Contains one YcaO_like domain (IPR003776).
      
 0.447
MCP_0555
Conserved hypothetical protein; Contains one TfuA-like, core domain (IPR012924).
      
 0.447
MCP_1427
Conserved hypothetical protein.
      
 0.447
mcrG
Methyl-coenzyme M reductase gamma subunit.
       0.418
MCP_1923
Putative transposase orfB for insertion sequence element.
       0.417
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.