node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MCP_1964 | aksA | MCP_1964 | MCP_1960 | Conserved hypothetical protein. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.593 |
MCP_1964 | aksF | MCP_1964 | MCP_1963 | Conserved hypothetical protein. | Putative threo-isocitrate dehydrogenase [NAD]. | 0.800 |
MCP_1964 | hacB | MCP_1964 | MCP_1962 | Conserved hypothetical protein. | 3-isopropylmalate dehydratase small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD f [...] | 0.800 |
MCP_1964 | leuC-3 | MCP_1964 | MCP_1961 | Conserved hypothetical protein. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.800 |
MCP_2808 | aksA | MCP_2808 | MCP_1960 | Putative 2-isopropylmalate synthase. | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.909 |
MCP_2808 | aksF | MCP_2808 | MCP_1963 | Putative 2-isopropylmalate synthase. | Putative threo-isocitrate dehydrogenase [NAD]. | 0.671 |
MCP_2808 | cimA | MCP_2808 | MCP_2701 | Putative 2-isopropylmalate synthase. | (R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 0.810 |
MCP_2808 | hacB | MCP_2808 | MCP_1962 | Putative 2-isopropylmalate synthase. | 3-isopropylmalate dehydratase small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD f [...] | 0.833 |
MCP_2808 | ilvC | MCP_2808 | MCP_2585 | Putative 2-isopropylmalate synthase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.791 |
MCP_2808 | ilvN | MCP_2808 | MCP_2699 | Putative 2-isopropylmalate synthase. | Acetolactate synthase small subunit. | 0.932 |
MCP_2808 | leuC | MCP_2808 | MCP_2991 | Putative 2-isopropylmalate synthase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.965 |
MCP_2808 | leuC-2 | MCP_2808 | MCP_1461 | Putative 2-isopropylmalate synthase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.962 |
MCP_2808 | leuC-3 | MCP_2808 | MCP_1961 | Putative 2-isopropylmalate synthase. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.825 |
aksA | MCP_1964 | MCP_1960 | MCP_1964 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Conserved hypothetical protein. | 0.593 |
aksA | MCP_2808 | MCP_1960 | MCP_2808 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Putative 2-isopropylmalate synthase. | 0.909 |
aksA | aksF | MCP_1960 | MCP_1963 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Putative threo-isocitrate dehydrogenase [NAD]. | 0.998 |
aksA | hacB | MCP_1960 | MCP_1962 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase small subunit; Hydro-lyase with broad substrate specificity for cis- unsaturated tricarboxylic acids. Catalyzes both the reversible dehydration of (R)-homocitrate ((R)-2-hydroxybutane-1,2,4- tricarboxylate) to produce cis-homoaconitate ((Z)-but-1-ene-1,2,4- tricarboxylate), and its hydration to homoisocitrate ((1R,2S)-1- hydroxybutane-1,2,4-tricarboxylate). Is also able to hydrate the analogous longer chain substrates cis-homo(2)-aconitate, cis-homo(3)- aconitate. All these reactions are part of the biosynthesis pathway of coenzyme B; Belongs to the LeuD f [...] | 0.983 |
aksA | ilvC | MCP_1960 | MCP_2585 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.791 |
aksA | ilvN | MCP_1960 | MCP_2699 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | Acetolactate synthase small subunit. | 0.677 |
aksA | leuC | MCP_1960 | MCP_2991 | Homocitrate synthase; Belongs to the alpha-IPM synthase/homocitrate synthase family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.646 |