topA-2 protein (Methanocella paludicola) - STRING interaction network

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topA-2

DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] (704 aa)

Predicted Functional Partners:

MCP_2279

0.990

gatB

0.902

gatC

0.890

MCP_2438

0.820

smc

0.815

gatA

0.807

MCP_1422

0.806

rpoD

0.804

rpoA2

0.793

rpoA1

0.791

Your Current Organism:

Methanocella paludicola

NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCP_1422	MCP_2279	MCP_1422	MCP_2279	Putative DNA double-strand break repair Rad50 ATPase.	Putative ATP-dependent helicase.	0.964
MCP_1422	MCP_2438	MCP_1422	MCP_2438	Putative DNA double-strand break repair Rad50 ATPase.	Asparagine synthase.	0.433
MCP_1422	topA-2	MCP_1422	MCP_2442	Putative DNA double-strand break repair Rad50 ATPase.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.806
MCP_2279	MCP_1422	MCP_2279	MCP_1422	Putative ATP-dependent helicase.	Putative DNA double-strand break repair Rad50 ATPase.	0.964
MCP_2279	MCP_2438	MCP_2279	MCP_2438	Putative ATP-dependent helicase.	Asparagine synthase.	0.855
MCP_2279	rpoA1	MCP_2279	MCP_1218	Putative ATP-dependent helicase.	DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.513
MCP_2279	rpoA2	MCP_2279	MCP_1219	Putative ATP-dependent helicase.	DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.447
MCP_2279	rpoD	MCP_2279	MCP_2258	Putative ATP-dependent helicase.	DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.871
MCP_2279	smc	MCP_2279	MCP_0628	Putative ATP-dependent helicase.	Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family.	0.992
MCP_2279	topA-2	MCP_2279	MCP_2442	Putative ATP-dependent helicase.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.990
MCP_2438	MCP_1422	MCP_2438	MCP_1422	Asparagine synthase.	Putative DNA double-strand break repair Rad50 ATPase.	0.433
MCP_2438	MCP_2279	MCP_2438	MCP_2279	Asparagine synthase.	Putative ATP-dependent helicase.	0.855
MCP_2438	gatA	MCP_2438	MCP_2440	Asparagine synthase.	glutamyl-tRNA(Gln) amidotransferase subunit A; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu- tRNA(Gln).	0.948
MCP_2438	gatB	MCP_2438	MCP_2441	Asparagine synthase.	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatB/GatE family. GatB subfamily.	0.986
MCP_2438	gatC	MCP_2438	MCP_2439	Asparagine synthase.	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C; Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl- tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp- tRNA(Asn) or phospho-Glu-tRNA(Gln); Belongs to the GatC family.	0.973
MCP_2438	rpoA1	MCP_2438	MCP_1218	Asparagine synthase.	DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.605
MCP_2438	rpoA2	MCP_2438	MCP_1219	Asparagine synthase.	DNA-directed RNA polymerase subunit A; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.605
MCP_2438	rpoD	MCP_2438	MCP_2258	Asparagine synthase.	DNA-directed RNA polymerase subunit D; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.544
MCP_2438	smc	MCP_2438	MCP_0628	Asparagine synthase.	Chromosome segregation protein SMC; Required for chromosome condensation and partitioning. Belongs to the SMC family.	0.713
MCP_2438	topA-2	MCP_2438	MCP_2442	Asparagine synthase.	DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]	0.820

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