| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCP_2483 | purP-2 | MCP_2483 | MCP_2481 | Putative oxidoreductase. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. | 0.675 |
| MCP_2483 | purP-3 | MCP_2483 | MCP_2482 | Putative oxidoreductase. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. | 0.668 |
| apt | guaAB | MCP_0400 | MCP_0413 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | 0.733 |
| apt | hisF | MCP_0400 | MCP_0335 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.849 |
| apt | hisH | MCP_0400 | MCP_0639 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.813 |
| apt | purB | MCP_0400 | MCP_2428 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.987 |
| apt | purD | MCP_0400 | MCP_2597 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.520 |
| apt | purP-1 | MCP_0400 | MCP_2462 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. | 0.901 |
| apt | purP-2 | MCP_0400 | MCP_2481 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. | 0.901 |
| apt | purP-3 | MCP_0400 | MCP_2482 | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. | 0.901 |
| guaAB | apt | MCP_0413 | MCP_0400 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.733 |
| guaAB | purB | MCP_0413 | MCP_2428 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.849 |
| guaAB | purD | MCP_0413 | MCP_2597 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.883 |
| guaAB | purP-2 | MCP_0413 | MCP_2481 | GMP synthase [glutamine-hydrolyzing] subunit B; Catalyzes the synthesis of GMP from XMP. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. | 0.653 |
| hisF | apt | MCP_0335 | MCP_0400 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of IMP that is energically less costly than de novo synthesis. Belongs to the purine/pyrimidine phosphoribosyltransferase family. Archaeal HPRT subfamily. | 0.849 |
| hisF | hisH | MCP_0335 | MCP_0639 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisF | purB | MCP_0335 | MCP_2428 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. | 0.862 |
| hisF | purD | MCP_0335 | MCP_2597 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. | 0.442 |
| hisF | purP-1 | MCP_0335 | MCP_2462 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase; Catalyzes the ATP- and formate-dependent formylation of 5- aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. | 0.802 |
| hisF | purP-2 | MCP_0335 | MCP_2481 | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 5-formaminoimidazole-4-carboxamide-1-(beta)-D- ribofuranosyl 5'-monophosphate synthetase. | 0.802 |
