| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCP_2371 | MCP_2619 | MCP_2371 | MCP_2619 | Putative cyclase. | Putative phosphatase, PHP family. | 0.582 |
| MCP_2619 | MCP_2371 | MCP_2619 | MCP_2371 | Putative phosphatase, PHP family. | Putative cyclase. | 0.582 |
| MCP_2619 | hisA | MCP_2619 | MCP_0907 | Putative phosphatase, PHP family. | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | 0.605 |
| MCP_2619 | hisB | MCP_2619 | MCP_0809 | Putative phosphatase, PHP family. | Imidazoleglycerol-phosphate dehydratase. | 0.727 |
| MCP_2619 | hisC | MCP_2619 | MCP_1006 | Putative phosphatase, PHP family. | Histidinol-phosphate aminotransferase. | 0.793 |
| MCP_2619 | hisD | MCP_2619 | MCP_0704 | Putative phosphatase, PHP family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.725 |
| MCP_2619 | hisF | MCP_2619 | MCP_0335 | Putative phosphatase, PHP family. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.678 |
| MCP_2619 | hisG | MCP_2619 | MCP_2779 | Putative phosphatase, PHP family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.719 |
| MCP_2619 | hisH | MCP_2619 | MCP_0639 | Putative phosphatase, PHP family. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.625 |
| MCP_2619 | hisI | MCP_2619 | MCP_0573 | Putative phosphatase, PHP family. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.742 |
| MCP_2619 | srp19 | MCP_2619 | MCP_2620 | Putative phosphatase, PHP family. | Signal recognition particle 19 kDa protein; Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP. | 0.582 |
| hisA | MCP_2619 | MCP_0907 | MCP_2619 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Putative phosphatase, PHP family. | 0.605 |
| hisA | hisB | MCP_0907 | MCP_0809 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.986 |
| hisA | hisC | MCP_0907 | MCP_1006 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase. | 0.937 |
| hisA | hisD | MCP_0907 | MCP_0704 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.997 |
| hisA | hisF | MCP_0907 | MCP_0335 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit HisF; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
| hisA | hisG | MCP_0907 | MCP_2779 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.989 |
| hisA | hisH | MCP_0907 | MCP_0639 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.999 |
| hisA | hisI | MCP_0907 | MCP_0573 | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.999 |
| hisB | MCP_2619 | MCP_0809 | MCP_2619 | Imidazoleglycerol-phosphate dehydratase. | Putative phosphatase, PHP family. | 0.727 |