| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCP_2629 | pfdB | MCP_2629 | MCP_2622 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 0.887 |
| MCP_2629 | psmA | MCP_2629 | MCP_2630 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.966 |
| MCP_2629 | rnp2 | MCP_2629 | MCP_2631 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | Ribonuclease P protein component 2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | 0.896 |
| MCP_2629 | rpl15e | MCP_2629 | MCP_2636 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | 50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.966 |
| MCP_2629 | rpl37ae | MCP_2629 | MCP_2625 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.992 |
| MCP_2629 | rrp4 | MCP_2629 | MCP_2628 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | Putative exosome complex RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.892 |
| MCP_2629 | rrp42 | MCP_2629 | MCP_2626 | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | Probable exosome complex exonuclease 2; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. | 0.904 |
| pan-1 | pan-2 | MCP_0253 | MCP_1002 | Proteasome-activating nucleotidase; Belongs to the AAA ATPase family. | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | 0.903 |
| pan-1 | psmA | MCP_0253 | MCP_2630 | Proteasome-activating nucleotidase; Belongs to the AAA ATPase family. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.924 |
| pan-1 | psmB | MCP_0253 | MCP_2399 | Proteasome-activating nucleotidase; Belongs to the AAA ATPase family. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.922 |
| pan-2 | pan-1 | MCP_1002 | MCP_0253 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome-activating nucleotidase; Belongs to the AAA ATPase family. | 0.903 |
| pan-2 | psmA | MCP_1002 | MCP_2630 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.935 |
| pan-2 | psmB | MCP_1002 | MCP_2399 | Proteasome-activating nucleotidase; ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C- termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase- [...] | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.922 |
| pfdB | MCP_2629 | MCP_2622 | MCP_2629 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Conserved hypothetical protein; Belongs to the Shwachman-Bodian-Diamond syndrome proteins family (IPR002140). | 0.887 |
| pfdB | psmA | MCP_2622 | MCP_2630 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Proteasome alpha subunit; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.911 |
| pfdB | psmB | MCP_2622 | MCP_2399 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Proteasome subunit beta; Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation. | 0.483 |
| pfdB | rnp2 | MCP_2622 | MCP_2631 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Ribonuclease P protein component 2; Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends; Belongs to the eukaryotic/archaeal RNase P protein component 2 family. | 0.727 |
| pfdB | rpl15e | MCP_2622 | MCP_2636 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 50S ribosomal protein L15e; Belongs to the eukaryotic ribosomal protein eL15 family. | 0.685 |
| pfdB | rpl37ae | MCP_2622 | MCP_2625 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | 50S ribosomal protein L37Ae; Binds to the 23S rRNA. | 0.937 |
| pfdB | rrp4 | MCP_2622 | MCP_2628 | Prefoldin beta subunit; Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. | Putative exosome complex RNA-binding protein; Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. | 0.930 |