STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ilvBAcetolactate synthase large subunit. (566 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase small subunit.
 0.999
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.995
MCP_1230
Alpha-acetolactate decarboxylase.
  
 
 0.986
cimA
(R)-citramalate synthase; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate; Belongs to the alpha-IPM synthase/homocitrate synthase family.
 
 
 0.980
leuB
3-isopropylmalate dehydrogenase.
 
 0.964
ilvD-2
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
  
 0.963
MCP_1257
Similar to Ketoisovalerate oxidoreductase alpha chain VorA in Pyrococcus furiosus (Q51801).
  
 
 0.930
MCP_2613
Similar to Pyruvate synthase alpha chain PorA in Pyrococcus furiosus (Q51804).
  
 
 0.930
MCP_1258
Pyruvate synthase beta chain; Similar to Ketoisovalerate oxidoreductase beta VorB in Pyrococcus furiosus (Q51802).
  
 
 0.929
MCP_2614
Similar to Pyruvate synthase beta chain PorB in Pyrococcus furiosus (Q51805).
  
 
 0.929
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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