Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lonATP-dependent protease La; Belongs to the peptidase S16 family. (636 aa)    
Predicted Functional Partners:
dnaK
Heat shock protein 70; Acts as a chaperone.
 
 0.950
grpE
HSP-70 cofactor; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependen [...]
 
  
 0.907
MCP_2697
ATP-dependent Clp protease ATP-binding subunit ClpA homolog.
  
 
 0.877
MCP_0636
Thermosome; Belongs to the TCP-1 chaperonin family.
  
 
 0.859
MCP_0664
Thermosome; Belongs to the TCP-1 chaperonin family.
  
 
 0.859
MCP_2307
Thermosome; Belongs to the TCP-1 chaperonin family.
  
 
 0.859
rps2p
30S ribosomal protein S2P; Belongs to the universal ribosomal protein uS2 family.
 
 0.856
ileS
isoleucyl-tRNA synthetase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.
  
 
 0.848
MCP_2747
Putative hydroxymethylglutaryl-coenzyme A synthase; Belongs to the thiolase-like superfamily. UPF0219 family.
 
 0.817
MCP_2748
acyl-CoA C-acyltransferases.
 
 
 0.816
Your Current Organism:
Methanocella paludicola
NCBI taxonomy Id: 304371
Other names: M. paludicola SANAE, Methanocella paludicola SANAE, methanogenic archaeon SANAE, methanogenic archaeon str. SANAE, methanogenic archaeon strain SANAE
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