node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A4W2BN79 | A0A4W2DWT4 | A0A4W2BN79 | A0A4W2DWT4 | Uncharacterized protein. | FHA domain-containing protein. | 0.818 |
A0A4W2BN79 | A0A4W2E367 | A0A4W2BN79 | A0A4W2E367 | Uncharacterized protein. | Histone H2A; Belongs to the histone H2A family. | 0.638 |
A0A4W2BN79 | MDC1 | A0A4W2BN79 | A0A4W2C526 | Uncharacterized protein. | BRCT domain-containing protein. | 0.818 |
A0A4W2DWT4 | A0A4W2BN79 | A0A4W2DWT4 | A0A4W2BN79 | FHA domain-containing protein. | Uncharacterized protein. | 0.818 |
A0A4W2DWT4 | A0A4W2E367 | A0A4W2DWT4 | A0A4W2E367 | FHA domain-containing protein. | Histone H2A; Belongs to the histone H2A family. | 0.800 |
A0A4W2DWT4 | ATM | A0A4W2DWT4 | A0A4W2DSM5 | FHA domain-containing protein. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.920 |
A0A4W2DWT4 | BRCA1 | A0A4W2DWT4 | A0A4W2EC46 | FHA domain-containing protein. | BRCA1 DNA repair associated. | 0.824 |
A0A4W2DWT4 | MDC1 | A0A4W2DWT4 | A0A4W2C526 | FHA domain-containing protein. | BRCT domain-containing protein. | 0.873 |
A0A4W2DWT4 | NBN | A0A4W2DWT4 | A0A4W2CAE8 | FHA domain-containing protein. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.856 |
A0A4W2DWT4 | RNF168 | A0A4W2DWT4 | A0A4W2D4V3 | FHA domain-containing protein. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.767 |
A0A4W2DWT4 | RNF8 | A0A4W2DWT4 | A0A4W2HHC3 | FHA domain-containing protein. | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] | 0.865 |
A0A4W2DWT4 | TOPBP1 | A0A4W2DWT4 | A0A4W2F086 | FHA domain-containing protein. | DNA topoisomerase II binding protein 1. | 0.784 |
A0A4W2DWT4 | TP53BP1 | A0A4W2DWT4 | A0A4W2DZN3 | FHA domain-containing protein. | Tumor protein p53 binding protein 1. | 0.894 |
A0A4W2E367 | A0A4W2BN79 | A0A4W2E367 | A0A4W2BN79 | Histone H2A; Belongs to the histone H2A family. | Uncharacterized protein. | 0.638 |
A0A4W2E367 | A0A4W2DWT4 | A0A4W2E367 | A0A4W2DWT4 | Histone H2A; Belongs to the histone H2A family. | FHA domain-containing protein. | 0.800 |
A0A4W2E367 | ATM | A0A4W2E367 | A0A4W2DSM5 | Histone H2A; Belongs to the histone H2A family. | Serine-protein kinase ATM; Serine/threonine protein kinase which activates checkpoint signaling upon double strand breaks (DSBs), apoptosis and genotoxic stresses such as ionizing ultraviolet A light (UVA), thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at double strand breaks (DSBs), thereby regulating DNA damage response mechanism. Also plays a role in pre-B cell allelic exclusion, a process leading to expression of a single immunoglobulin heavy chain allele to enforce clonality and mo [...] | 0.880 |
A0A4W2E367 | BRCA1 | A0A4W2E367 | A0A4W2EC46 | Histone H2A; Belongs to the histone H2A family. | BRCA1 DNA repair associated. | 0.841 |
A0A4W2E367 | MDC1 | A0A4W2E367 | A0A4W2C526 | Histone H2A; Belongs to the histone H2A family. | BRCT domain-containing protein. | 0.894 |
A0A4W2E367 | NBN | A0A4W2E367 | A0A4W2CAE8 | Histone H2A; Belongs to the histone H2A family. | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. | 0.513 |
A0A4W2E367 | RNF168 | A0A4W2E367 | A0A4W2D4V3 | Histone H2A; Belongs to the histone H2A family. | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] | 0.874 |