STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MCPH1Microcephalin 1. (872 aa)    
Predicted Functional Partners:
WRN
WRN RecQ like helicase.
   
 0.893
SLF1
SMC5-SMC6 complex localization factor 1.
   
 0.884
TERF2
Telomeric repeat binding factor 2.
    
  0.804
TOPBP1
DNA topoisomerase II binding protein 1.
   
 0.786
BRCA2
BRCA2 DNA repair associated.
   
 0.770
ASPM
Abnormal spindle microtubule assembly.
   
  
 0.746
MRE11
MRE11 homolog, double strand break repair nuclease; Belongs to the MRE11/RAD32 family.
   
 0.744
REL
REL proto-oncogene, NF-kB subunit.
    
 0.739
NBN
Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.
    
 0.738
ABRAXAS1
Abraxas 1, BRCA1 A complex subunit.
    
 0.735
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.