STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SPIDRScaffold protein involved in DNA repair. (831 aa)    
Predicted Functional Partners:
SWSAP1
SWIM-type zinc finger 7 associated protein 1.
    
 
 0.723
FIGNL1
Fidgetin like 1; Belongs to the AAA ATPase family.
    
 
 0.715
UNC79
Unc-79 homolog, NALCN channel complex subunit.
      
 0.709
WRN
WRN RecQ like helicase.
    
 0.648
AMOTL1
Angiomotin like 1.
      
 0.598
ERCC6L2
Uncharacterized protein.
      
 0.582
STRBP
Spermatid perinuclear RNA binding protein.
      
 0.578
MAN2A1
Alpha-mannosidase.
      
 0.574
ZFYVE26
Zinc finger FYVE-type containing 26.
      
 0.571
TOP3A
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
   
  0.547
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.