STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEDD8NEDD8 ubiquitin like modifier. (81 aa)    
Predicted Functional Partners:
UBA3
Ubiquitin like modifier activating enzyme 3.
   
 0.998
UBE2M
Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family.
   
 0.997
NAE1
NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.
   
 0.980
CUL5
Cullin 5; Belongs to the cullin family.
    
 0.979
A0A4W2FLF9
RING-type domain-containing protein.
   
 0.977
RBX1
RING-type domain-containing protein.
   
 0.977
CUL2
Cullin 2; Belongs to the cullin family.
    
 0.975
COPS6
COP9 signalosome subunit 6.
   
 0.970
COPS5
COP9 signalosome subunit 5.
   
 0.970
CUL3
Cullin 3; Belongs to the cullin family.
    
 0.967
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.