STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)    
Predicted Functional Partners:
CDK5R2
Cyclin dependent kinase 5 regulatory subunit 2.
    
 0.997
MAPT
Microtubule-associated protein.
    
 0.974
PPP1R1B
Protein phosphatase 1 regulatory inhibitor subunit 1B.
    
 0.966
DPYSL2
Dihydropyrimidinase like 2.
     
 0.953
DLG4
Discs large MAGUK scaffold protein 4; Belongs to the MAGUK family.
    
 0.918
FYN
Tyrosine-protein kinase.
    
0.904
TP53
Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.
    
 0.895
DPYS
Dihydropyrimidinase.
     
 0.831
CABLES1
Cdk5 and Abl enzyme substrate 1.
    
 0.828
MAP2
Microtubule-associated protein.
    
 0.771
Your Current Organism:
Bos indicus
NCBI taxonomy Id: 30522
Other names: B. indicus x Bos taurus, Bos indicus x Bos taurus, Bos primigenius indicus x Bos primigenius taurus, Bos taurus indicus x Bos taurus taurus, hybrid cattle
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.