node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
A0A4W2BND6 | A0A4W2C9G4 | A0A4W2BND6 | A0A4W2C9G4 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncharacterized protein. | 0.420 |
A0A4W2BND6 | EPO | A0A4W2BND6 | A0A4W2BL42 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.487 |
A0A4W2BND6 | GHR | A0A4W2BND6 | A0A4W2E824 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Growth hormone receptor. | 0.463 |
A0A4W2BND6 | IL6 | A0A4W2BND6 | A0A4W2EXX6 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Interleukin 6. | 0.577 |
A0A4W2BND6 | JAK2 | A0A4W2BND6 | A0A4W2I4Q1 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase. | 0.464 |
A0A4W2BND6 | LEP | A0A4W2BND6 | A0A4W2CXJ2 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.594 |
A0A4W2BND6 | LOC113881914 | A0A4W2BND6 | A0A4W2FFJ6 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncharacterized protein. | 0.597 |
A0A4W2BND6 | POMC | A0A4W2BND6 | A0A4W2GZR4 | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Proopiomelanocortin. | 0.595 |
A0A4W2C5I5 | A0A4W2C9G4 | A0A4W2C5I5 | A0A4W2C9G4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncharacterized protein. | 0.420 |
A0A4W2C5I5 | EPO | A0A4W2C5I5 | A0A4W2BL42 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.487 |
A0A4W2C5I5 | GHR | A0A4W2C5I5 | A0A4W2E824 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Growth hormone receptor. | 0.463 |
A0A4W2C5I5 | IL6 | A0A4W2C5I5 | A0A4W2EXX6 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Interleukin 6. | 0.577 |
A0A4W2C5I5 | JAK2 | A0A4W2C5I5 | A0A4W2I4Q1 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Tyrosine-protein kinase. | 0.551 |
A0A4W2C5I5 | LEP | A0A4W2C5I5 | A0A4W2CXJ2 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo- pituitary-adrenal hormones. In the periphery, increases basal me [...] | 0.646 |
A0A4W2C5I5 | LOC113881914 | A0A4W2C5I5 | A0A4W2FFJ6 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Uncharacterized protein. | 0.597 |
A0A4W2C5I5 | POMC | A0A4W2C5I5 | A0A4W2GZR4 | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | Proopiomelanocortin. | 0.624 |
A0A4W2C9G4 | A0A4W2BND6 | A0A4W2C9G4 | A0A4W2BND6 | Uncharacterized protein. | IlGF domain-containing protein; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.420 |
A0A4W2C9G4 | A0A4W2C5I5 | A0A4W2C9G4 | A0A4W2C5I5 | Uncharacterized protein. | Insulin; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. | 0.420 |
A0A4W2C9G4 | EPO | A0A4W2C9G4 | A0A4W2BL42 | Uncharacterized protein. | Erythropoietin; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. Belongs to the EPO/TPO family. | 0.840 |
A0A4W2C9G4 | GHR | A0A4W2C9G4 | A0A4W2E824 | Uncharacterized protein. | Growth hormone receptor. | 0.987 |