node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CASP8 | FADD | A0A4W2INM4 | A0A4W2CDD9 | Caspase 8; Belongs to the peptidase C14A family. | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | 0.999 |
CASP8 | LOC113888945 | A0A4W2INM4 | A0A4W2DUB6 | Caspase 8; Belongs to the peptidase C14A family. | Uncharacterized protein. | 0.561 |
CASP8 | RIPK1 | A0A4W2INM4 | A0A4W2GXE3 | Caspase 8; Belongs to the peptidase C14A family. | Receptor interacting serine/threonine kinase 1. | 0.995 |
CASP8 | TNF | A0A4W2INM4 | A0A4W2EFB5 | Caspase 8; Belongs to the peptidase C14A family. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.941 |
CASP8 | TNFRSF1A | A0A4W2INM4 | A0A4W2DYN6 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor superfamily member 1A. | 0.702 |
CASP8 | TRADD | A0A4W2INM4 | A0A4W2GHE2 | Caspase 8; Belongs to the peptidase C14A family. | TNFRSF1A associated via death domain. | 0.995 |
CASP8 | TRAF1 | A0A4W2INM4 | A0A4W2CZ17 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor-associated factor. | 0.948 |
CASP8 | TRAF2 | A0A4W2INM4 | A0A4W2BT37 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.892 |
CASP8 | TRAF3 | A0A4W2INM4 | A0A4W2FZ99 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.762 |
CASP8 | TRAF5 | A0A4W2INM4 | A0A4W2C4Q4 | Caspase 8; Belongs to the peptidase C14A family. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.749 |
FADD | CASP8 | A0A4W2CDD9 | A0A4W2INM4 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Caspase 8; Belongs to the peptidase C14A family. | 0.999 |
FADD | LOC113888945 | A0A4W2CDD9 | A0A4W2DUB6 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Uncharacterized protein. | 0.938 |
FADD | RIPK1 | A0A4W2CDD9 | A0A4W2GXE3 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Receptor interacting serine/threonine kinase 1. | 0.997 |
FADD | TNF | A0A4W2CDD9 | A0A4W2EFB5 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | Tumor necrosis factor; Belongs to the tumor necrosis factor family. | 0.770 |
FADD | TNFRSF1A | A0A4W2CDD9 | A0A4W2DYN6 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor superfamily member 1A. | 0.984 |
FADD | TRADD | A0A4W2CDD9 | A0A4W2GHE2 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNFRSF1A associated via death domain. | 0.998 |
FADD | TRAF1 | A0A4W2CDD9 | A0A4W2CZ17 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor. | 0.777 |
FADD | TRAF2 | A0A4W2CDD9 | A0A4W2BT37 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.958 |
FADD | TRAF3 | A0A4W2CDD9 | A0A4W2FZ99 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.670 |
FADD | TRAF5 | A0A4W2CDD9 | A0A4W2C4Q4 | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.652 |