node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGO2 | SND1 | A0A4W2C406 | A0A4W2I564 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.647 |
AGO2 | TSNAX | A0A4W2C406 | A0A4W2C3A6 | Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] | Uncharacterized protein. | 0.917 |
EGR1 | PLK1 | A0A4W2DHW3 | A0A4W2BRV5 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Serine/threonine-protein kinase PLK. | 0.624 |
EGR1 | RBL2 | A0A4W2DHW3 | A0A4W2CAU9 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | RB transcriptional corepressor like 2. | 0.597 |
EGR1 | SND1 | A0A4W2DHW3 | A0A4W2I564 | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.677 |
GANAB | P4HB | A0A4W2E8E9 | A0A4W2CB64 | Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. | Protein disulfide-isomerase. | 0.593 |
GANAB | SND1 | A0A4W2E8E9 | A0A4W2I564 | Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.775 |
MTDH | SND1 | A0A4W2EL98 | A0A4W2I564 | Metadherin. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.934 |
P4HB | GANAB | A0A4W2CB64 | A0A4W2E8E9 | Protein disulfide-isomerase. | Glucosidase II alpha subunit; Belongs to the glycosyl hydrolase 31 family. | 0.593 |
P4HB | SEC61A1 | A0A4W2CB64 | A0A4W2FHK1 | Protein disulfide-isomerase. | SEC61 translocon alpha 1 subunit. | 0.774 |
P4HB | SEC61A2 | A0A4W2CB64 | A0A4W2HMB5 | Protein disulfide-isomerase. | SEC61 translocon alpha 2 subunit. | 0.707 |
P4HB | SND1 | A0A4W2CB64 | A0A4W2I564 | Protein disulfide-isomerase. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.772 |
PLK1 | EGR1 | A0A4W2BRV5 | A0A4W2DHW3 | Serine/threonine-protein kinase PLK. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.624 |
PLK1 | RBL2 | A0A4W2BRV5 | A0A4W2CAU9 | Serine/threonine-protein kinase PLK. | RB transcriptional corepressor like 2. | 0.725 |
PLK1 | SND1 | A0A4W2BRV5 | A0A4W2I564 | Serine/threonine-protein kinase PLK. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.731 |
RBL2 | EGR1 | A0A4W2CAU9 | A0A4W2DHW3 | RB transcriptional corepressor like 2. | Early growth response protein; Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. Belongs to the EGR C2H2-type zinc-finger protein family. | 0.597 |
RBL2 | PLK1 | A0A4W2CAU9 | A0A4W2BRV5 | RB transcriptional corepressor like 2. | Serine/threonine-protein kinase PLK. | 0.725 |
RBL2 | SND1 | A0A4W2CAU9 | A0A4W2I564 | RB transcriptional corepressor like 2. | Staphylococcal nuclease domain-containing protein; Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. | 0.723 |
SEC61A1 | P4HB | A0A4W2FHK1 | A0A4W2CB64 | SEC61 translocon alpha 1 subunit. | Protein disulfide-isomerase. | 0.774 |
SEC61A1 | SEC61A2 | A0A4W2FHK1 | A0A4W2HMB5 | SEC61 translocon alpha 1 subunit. | SEC61 translocon alpha 2 subunit. | 0.817 |