Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TDP1tyrosyl-DNA phosphodiesterase 1. (508 aa)    
Predicted Functional Partners:
LIG3
DNA ligase 3.
   
 
 0.992
TOP1
DNA topoisomerase I.
    
 
 0.984
POLB
DNA polymerase beta.
    
 
 0.983
ERCC4
ERCC excision repair 4, endonuclease catalytic subunit.
   
 
 0.958
ENSVPAP00000011245
annotation not available
    
 
 0.950
ENSVPAP00000011636
annotation not available
    
 
 0.950
APTX
Aprataxin.
    
 
 0.938
APEX1
Apurinic/apyrimidinic endodeoxyribonuclease 1.
   
 
 0.929
PNKP
Polynucleotide kinase 3'-phosphatase.
    
 
 0.924
FANCM
FA complementation group M.
   
 
 0.922
Your Current Organism:
Vicugna pacos
NCBI taxonomy Id: 30538
Other names: Lama guanicoe pacos, Lama pacos, V. pacos, alpaca
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