LYRM2 protein (Microcebus murinus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

LYRM2

annotation not available (88 aa)

Predicted Functional Partners:

OXSM

0.773

NDUFAB1

0.631

ENSMICP00000036611

0.631

PALB2

0.482

ETFRF1

0.478

LYRM1

0.463

LYRM9

0.447

ENSMICP00000031231

0.433

SDHAF3

0.424

WDR55

0.410

Your Current Organism:

Microcebus murinus

NCBI taxonomy Id: 30608
Other names: M. murinus, gray mouse lemur, grey mouse lemur

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMICP00000031231	ENSMICP00000036611	ENSMICP00000031231	ENSMICP00000036611	annotation not available	annotation not available	0.946
ENSMICP00000031231	ETFRF1	ENSMICP00000031231	ENSMICP00000030759	annotation not available	Electron transfer flavoprotein regulatory factor 1.	0.547
ENSMICP00000031231	LYRM1	ENSMICP00000031231	ENSMICP00000019150	annotation not available	LYR motif containing 1.	0.550
ENSMICP00000031231	LYRM2	ENSMICP00000031231	ENSMICP00000026342	annotation not available	annotation not available	0.433
ENSMICP00000031231	NDUFAB1	ENSMICP00000031231	ENSMICP00000007078	annotation not available	annotation not available	0.946
ENSMICP00000031231	OXSM	ENSMICP00000031231	ENSMICP00000051293	annotation not available	3-oxoacyl-ACP synthase, mitochondrial.	0.478
ENSMICP00000031231	PALB2	ENSMICP00000031231	ENSMICP00000043319	annotation not available	Partner and localizer of BRCA2.	0.939
ENSMICP00000031231	SDHAF3	ENSMICP00000031231	ENSMICP00000047565	annotation not available	annotation not available	0.578
ENSMICP00000036611	ENSMICP00000031231	ENSMICP00000036611	ENSMICP00000031231	annotation not available	annotation not available	0.946
ENSMICP00000036611	ETFRF1	ENSMICP00000036611	ENSMICP00000030759	annotation not available	Electron transfer flavoprotein regulatory factor 1.	0.833
ENSMICP00000036611	LYRM1	ENSMICP00000036611	ENSMICP00000019150	annotation not available	LYR motif containing 1.	0.405
ENSMICP00000036611	LYRM2	ENSMICP00000036611	ENSMICP00000026342	annotation not available	annotation not available	0.631
ENSMICP00000036611	OXSM	ENSMICP00000036611	ENSMICP00000051293	annotation not available	3-oxoacyl-ACP synthase, mitochondrial.	0.994
ENSMICP00000036611	SDHAF3	ENSMICP00000036611	ENSMICP00000047565	annotation not available	annotation not available	0.751
ETFRF1	ENSMICP00000031231	ENSMICP00000030759	ENSMICP00000031231	Electron transfer flavoprotein regulatory factor 1.	annotation not available	0.547
ETFRF1	ENSMICP00000036611	ENSMICP00000030759	ENSMICP00000036611	Electron transfer flavoprotein regulatory factor 1.	annotation not available	0.833
ETFRF1	LYRM1	ENSMICP00000030759	ENSMICP00000019150	Electron transfer flavoprotein regulatory factor 1.	LYR motif containing 1.	0.576
ETFRF1	LYRM2	ENSMICP00000030759	ENSMICP00000026342	Electron transfer flavoprotein regulatory factor 1.	annotation not available	0.478
ETFRF1	NDUFAB1	ENSMICP00000030759	ENSMICP00000007078	Electron transfer flavoprotein regulatory factor 1.	annotation not available	0.833
ETFRF1	PALB2	ENSMICP00000030759	ENSMICP00000043319	Electron transfer flavoprotein regulatory factor 1.	Partner and localizer of BRCA2.	0.689

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Network Stats

number of nodes:

11

number of edges:

54

average node degree:

9.82

avg. local clustering coefficient:

0.982

expected number of edges:

16

PPI enrichment p-value:

5.44e-14

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015031

Protein transport

9 of 110

1.51

2.68

4.74e-10

GO:0044718

Siderophore transmembrane transport

3 of 20

1.77

1.29

0.0023

GO:0055085

Transmembrane transport

8 of 414

0.88

0.81

0.00015

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031992

Energy transducer activity

3 of 4

2.47

2.12

0.00011

GO:0015343

Siderophore transmembrane transporter activity

3 of 28

1.63

0.97

0.0100

GO:0022857

Transmembrane transporter activity

9 of 432

0.92

0.9

3.60e-05

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030288

Outer membrane-bounded periplasmic space

3 of 44

1.43

1.03

0.0042

GO:0005886

Plasma membrane

9 of 653

0.74

0.64

0.00023

GO:0016021

Integral component of membrane

9 of 967

0.57

0.44

0.0022

GO:0016020

Membrane

10 of 1384

0.46

0.37

0.0023

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:5771

Mixed, incl. TonB, C-terminal, and MotA/TolQ/ExbB proton channel

9 of 20

2.25

6.96

6.73e-17

CL:5772

Mixed, incl. MotA/TolQ/ExbB proton channel, and Energy transducer activity

7 of 13

2.33

5.82

3.74e-13

CL:5763

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

11 of 63

1.84

5.22

1.49e-17

CL:5764

TonB-dependent receptor-like, beta-barrel domain superfamily, and Protein transport

10 of 56

1.85

5.01

4.05e-16

CL:5786

Mixed, incl. Putative MotA/TolQ/ExbB family protein, and Energy transducer activity

5 of 6

2.52

4.56

1.30e-09

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01503

Cationic antimicrobial peptide (CAMP) resistance

5 of 88

1.35

1.33

0.00022

map02010

ABC transporters

5 of 166

1.08

0.86

0.0022

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0653

Protein transport

9 of 45

1.9

4.8

4.36e-14

KW-0735

Signal-anchor

3 of 5

2.38

2.25

5.28e-05

KW-0997

Cell inner membrane

3 of 81

1.17

0.59

0.0404

KW-0812

Transmembrane

9 of 949

0.57

0.44

0.0024

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02472

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.82

2.91e-08

PF03544

Gram-negative bacterial TonB protein C-terminal

3 of 7

2.23

1.75

0.00046

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003400

Biopolymer transport protein ExbD/TolR

5 of 8

2.39

3.63

7.46e-08

IPR003538

Gram-negative bacterial TonB protein

3 of 4

2.47

1.86

0.00035

IPR037682

TonB, C-terminal

3 of 7

2.23

1.63

0.00079

IPR006260

TonB/TolA, C-terminal

3 of 7

2.23

1.63

0.00079

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