ZNF286A protein (Microcebus murinus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

ZNF286A

annotation not available (516 aa)

Predicted Functional Partners:

ENSMICP00000013230

0.818

ENSMICP00000041567

0.818

TRIM28

0.524

LAMTOR2

0.497

MRPS11

0.494

MRPS15

0.490

MRPS9

0.489

MRPS6

0.489

MRPS28

0.489

MRPS16

0.489

Your Current Organism:

Microcebus murinus

NCBI taxonomy Id: 30608
Other names: M. murinus, gray mouse lemur, grey mouse lemur

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSMICP00000013230	ENSMICP00000041567	ENSMICP00000013230	ENSMICP00000041567	annotation not available	annotation not available	0.996
ENSMICP00000013230	MRPS11	ENSMICP00000013230	ENSMICP00000014421	annotation not available	Mitochondrial ribosomal protein S11.	0.598
ENSMICP00000013230	MRPS9	ENSMICP00000013230	ENSMICP00000000203	annotation not available	Mitochondrial ribosomal protein S9.	0.661
ENSMICP00000013230	ZNF286A	ENSMICP00000013230	ENSMICP00000033982	annotation not available	annotation not available	0.818
ENSMICP00000041567	ENSMICP00000013230	ENSMICP00000041567	ENSMICP00000013230	annotation not available	annotation not available	0.996
ENSMICP00000041567	MRPS11	ENSMICP00000041567	ENSMICP00000014421	annotation not available	Mitochondrial ribosomal protein S11.	0.598
ENSMICP00000041567	MRPS9	ENSMICP00000041567	ENSMICP00000000203	annotation not available	Mitochondrial ribosomal protein S9.	0.661
ENSMICP00000041567	ZNF286A	ENSMICP00000041567	ENSMICP00000033982	annotation not available	annotation not available	0.818
LAMTOR2	ZNF286A	ENSMICP00000002035	ENSMICP00000033982	Late endosomal/lysosomal adaptor, MAPK and MTOR activator 2.	annotation not available	0.497
MRPS11	ENSMICP00000013230	ENSMICP00000014421	ENSMICP00000013230	Mitochondrial ribosomal protein S11.	annotation not available	0.598
MRPS11	ENSMICP00000041567	ENSMICP00000014421	ENSMICP00000041567	Mitochondrial ribosomal protein S11.	annotation not available	0.598
MRPS11	MRPS15	ENSMICP00000014421	ENSMICP00000045467	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S15.	0.999
MRPS11	MRPS16	ENSMICP00000014421	ENSMICP00000045233	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S16.	0.999
MRPS11	MRPS28	ENSMICP00000014421	ENSMICP00000043549	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S28.	0.997
MRPS11	MRPS6	ENSMICP00000014421	ENSMICP00000021515	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S6.	0.999
MRPS11	MRPS9	ENSMICP00000014421	ENSMICP00000000203	Mitochondrial ribosomal protein S11.	Mitochondrial ribosomal protein S9.	0.999
MRPS11	ZNF286A	ENSMICP00000014421	ENSMICP00000033982	Mitochondrial ribosomal protein S11.	annotation not available	0.494
MRPS15	MRPS11	ENSMICP00000045467	ENSMICP00000014421	Mitochondrial ribosomal protein S15.	Mitochondrial ribosomal protein S11.	0.999
MRPS15	MRPS16	ENSMICP00000045467	ENSMICP00000045233	Mitochondrial ribosomal protein S15.	Mitochondrial ribosomal protein S16.	0.999
MRPS15	MRPS28	ENSMICP00000045467	ENSMICP00000043549	Mitochondrial ribosomal protein S15.	Mitochondrial ribosomal protein S28.	0.997

page 1 of 3

Network Stats

number of nodes:

5

number of edges:

4

average node degree:

1.6

avg. local clustering coefficient:

0.8

expected number of edges:

4

PPI enrichment p-value:

0.569

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042060

Wound healing

4 of 152

2.08

2.31

0.00013

GO:0007596

Blood coagulation

3 of 84

2.21

1.76

0.0017

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004252

Serine-type endopeptidase activity

3 of 201

1.83

1.01

0.0225

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17743

Mixed, incl. Fibronectin type II domain, and Establishment of epithelial cell apical/basal polarity

3 of 5

3.44

3.88

1.81e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0420

Kringle

3 of 20

2.83

3.6

3.42e-06

KW-0245

EGF-like domain

3 of 257

1.72

1.44

0.0027

KW-0964

Secreted

3 of 296

1.66

1.39

0.0028

KW-0720

Serine protease

2 of 88

2.01

1.24

0.0105

KW-1015

Disulfide bond

4 of 1497

1.08

0.78

0.0102

(more ...)

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR038178

Kringle superfamily

3 of 20

2.83

2.72

8.08e-05

IPR000001

Kringle

3 of 20

2.83

2.72

8.08e-05

IPR013806

Kringle-like fold

3 of 33

2.62

2.59

0.00011

IPR018114

Serine proteases, trypsin family, histidine active site

3 of 99

2.14

1.71

0.0019

IPR001314

Peptidase S1A, chymotrypsin family

3 of 111

2.09

1.65

0.0022

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00130

Kringle domain

3 of 20

2.83

3.35

8.45e-06

SM00020

Trypsin-like serine protease

3 of 137

2.0

1.78

0.0011

SM00181

Epidermal growth factor-like domain.

3 of 255

1.73

1.34

0.0044

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