Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RASGEF1BRasGEF domain family member 1B. (476 aa)    
Predicted Functional Partners:
SOS1
SOS Ras/Rac guanine nucleotide exchange factor 1.
    
 0.772
GRB2
Growth factor receptor bound protein 2.
     
 0.708
UNC5D
Unc-5 netrin receptor D.
      
 0.690
PRKG2
cGMP-dependent protein kinase.
      
 0.690
HAUS8
HAUS augmin like complex subunit 8.
      
 0.680
SLC26A3
Chloride anion exchanger; Chloride/bicarbonate exchanger. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.
   
  
 0.679
DLL1
Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.
      
 0.653
LINGO1
Leucine rich repeat and Ig domain containing 1.
   
  
 0.627
SOS2
SOS Ras/Rho guanine nucleotide exchange factor 2.
    
 0.626
RASA1
RAS p21 protein activator 1.
    
 
 0.599
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.