Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
RHOT1Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family. (607 aa)    
Predicted Functional Partners:
PRKN
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.
    
 0.996
RHOT2
Mitochondrial Rho GTPase; Mitochondrial GTPase involved in mitochondrial trafficking. Belongs to the mitochondrial Rho GTPase family.
   
 0.990
TRAK1
Trafficking kinesin protein 1.
    
 0.986
TRAK2
Trafficking kinesin protein 2.
    
 0.954
MFN2
Mitofusin 2; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
  
 0.950
TOMM70
Translocase of outer mitochondrial membrane 70.
   
 0.944
MFN1
Mitofusin 1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.
   
 0.942
MYO19
Myosin XIX; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.
    
 0.940
MARCHF5
Membrane associated ring-CH-type finger 5.
    
 0.912
USP30
Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family.
     
 0.907
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.