Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
H0WIA8_OTOGANACHT domain-containing protein. (717 aa)    
Predicted Functional Partners:
PYCARD
PYD and CARD domain containing.
   
 0.977
IL1B
Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family.
   
 0.876
NEK7
NIMA related kinase 7; Belongs to the protein kinase superfamily.
    
 0.863
MAVS
Mitochondrial antiviral signaling protein.
    
 0.853
GSDMD
Gasdermin D.
     
 0.847
NLRP2
Uncharacterized protein.
   
 
 0.839
RCN1
Uncharacterized protein.
    
   0.806
TXNIP
Thioredoxin interacting protein.
    
 0.806
TCL1A
T cell leukemia/lymphoma 1A.
    
   0.801
CASP12
Caspase 12 (gene/pseudogene); Belongs to the peptidase C14A family.
   
 0.798
Your Current Organism:
Otolemur garnettii
NCBI taxonomy Id: 30611
Other names: Galago garnetti, Galago garnettii, O. garnettii, small-eared galago
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